2f4w: Difference between revisions

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[[Image:2f4w.gif|left|200px]]
{{Seed}}
[[Image:2f4w.png|left|200px]]


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{{STRUCTURE_2f4w|  PDB=2f4w  |  SCENE=  }}  
{{STRUCTURE_2f4w|  PDB=2f4w  |  SCENE=  }}  


'''Human ubiquitin-conjugating enzyme E2 J2'''
===Human ubiquitin-conjugating enzyme E2 J2===


==Overview==
Degradation of proteins from the endoplasmic reticulum is fundamental to quality control within the secretory pathway, serves as a way of regulating levels of crucial proteins, and is utilized by viruses to enhance pathogenesis. In yeast two ubiquitin-conjugating enzymes (E2s), UBC6p and UBC7p are implicated in this process. We now report the characterization of murine homologs of these E2s. MmUBC6 is an integral membrane protein that is anchored via its hydrophobic C-terminal tail to the endoplasmic reticulum. MmUBC7, which is not an integral membrane protein, shows significant endoplasmic reticulum colocalization with MmUBC6. Overexpression of catalytically inactive MmUBC7 significantly delayed degradation from the endoplasmic reticulum of two T cell antigen receptor subunits, alpha and CD3-delta, and suggests a role for the ubiquitin conjugating system at the initiation of retrograde movement from the endoplasmic reticulum. These findings also implicate, for the first time, a specific E2 in degradation from the endoplasmic reticulum in mammalian cells.


==About this Structure==
==About this Structure==
2F4W is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F4W OCA].  
2F4W is a 2 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2F4W OCA].  


==Reference==
==Reference==
Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s)., Tiwari S, Weissman AM, J Biol Chem. 2001 May 11;276(19):16193-200. Epub 2001 Feb 2. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11278356 11278356]
<ref group="xtra">PMID:11278356</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Single protein]]
[[Category: Ubiquitin--protein ligase]]
[[Category: Ubiquitin--protein ligase]]
[[Category: Arrowsmith, C.]]
[[Category: Arrowsmith, C.]]
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[[Category: Ligase]]
[[Category: Ligase]]
[[Category: Ubl conjugation pathway]]
[[Category: Ubl conjugation pathway]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:27:48 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 15:02:12 2009''

Revision as of 13:02, 16 February 2009

File:2f4w.png

Template:STRUCTURE 2f4w

Human ubiquitin-conjugating enzyme E2 J2

About this Structure

2F4W is a 2 chains structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Tiwari S, Weissman AM. Endoplasmic reticulum (ER)-associated degradation of T cell receptor subunits. Involvement of ER-associated ubiquitin-conjugating enzymes (E2s). J Biol Chem. 2001 May 11;276(19):16193-200. Epub 2001 Feb 2. PMID:11278356 doi:https://dx.doi.org/10.1074/jbc.M007640200

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