2f5o: Difference between revisions

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[[Image:2f5o.gif|left|200px]]
{{Seed}}
[[Image:2f5o.png|left|200px]]


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{{STRUCTURE_2f5o|  PDB=2f5o  |  SCENE=  }}  
{{STRUCTURE_2f5o|  PDB=2f5o  |  SCENE=  }}  


'''MutM crosslinked to undamaged DNA sampling G:C base pair IC3'''
===MutM crosslinked to undamaged DNA sampling G:C base pair IC3===




==Overview==
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DNA glycosylases must interrogate millions of base pairs of undamaged DNA in order to locate and then excise one damaged nucleobase. The nature of this search process remains poorly understood. Here we report the use of disulfide cross-linking (DXL) technology to obtain structures of a bacterial DNA glycosylase, MutM, interrogating undamaged DNA. These structures, solved to 2.0 angstrom resolution, reveal the nature of the search process: The protein inserts a probe residue into the helical stack and severely buckles the target base pair, which remains intrahelical. MutM therefore actively interrogates the intact DNA helix while searching for damage.
The line below this paragraph, {{ABSTRACT_PUBMED_16497933}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16497933}}


==About this Structure==
==About this Structure==
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[[Category: Dna glycosylase]]
[[Category: Dna glycosylase]]
[[Category: Dna repair]]
[[Category: Dna repair]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:29:24 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:20:14 2008''

Revision as of 12:20, 27 July 2008

File:2f5o.png

Template:STRUCTURE 2f5o

MutM crosslinked to undamaged DNA sampling G:C base pair IC3

Template:ABSTRACT PUBMED 16497933

About this Structure

2F5O is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

Structure of a DNA glycosylase searching for lesions., Banerjee A, Santos WL, Verdine GL, Science. 2006 Feb 24;311(5764):1153-7. PMID:16497933

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