2f8v: Difference between revisions

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[[Image:2f8v.gif|left|200px]]
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[[Image:2f8v.png|left|200px]]


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{{STRUCTURE_2f8v|  PDB=2f8v  |  SCENE=  }}  
{{STRUCTURE_2f8v|  PDB=2f8v  |  SCENE=  }}  


'''Structure of full length telethonin in complex with the N-terminus of titin'''
===Structure of full length telethonin in complex with the N-terminus of titin===




==Overview==
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The Z-disk region defines the lateral boundary of the sarcomere and requires a high level of mechanical strength to provide a stable framework for large filamentous muscle proteins. The level of complexity at this area is reflected by a large number of protein-protein interactions. Recently, we unraveled how the N-terminus of the longest filament component, the giant muscle protein titin, is assembled into an antiparallel (2:1) sandwich complex by the N-terminal titin-binding segment of the Z-disk ligand telethonin/T-cap [Zou, P., Pinotsis, N., Lange, S., Song, Y.H., Popov, A., Mavridis, I., Mayans, O.M., Gautel, M., Wilmanns, M., 2006. Palindromic assembly of the giant muscle protein titin in the sarcomeric Z-disk. Nature 439, 229-233]. In this contribution, we present structural data of a related complex of the titin N-terminus with full-length telethonin. The C-terminus of telethonin remains invisible, suggesting that it does not fold into a defined structure even in the presence of titin. In contrast to the structure with truncated telethonin, a dimer of two titin/telethonin complexes is formed within the crystal environment, potentially indicating the formation of higher oligomers. We further investigated the structure and dynamics of this assembly by small-angle X-ray scattering, circular dichroism, and in vivo complementation data. The data consistently indicate the involvement of the C-terminal part of telethonin into the assembly of two titin/telethonin complexes.
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{{ABSTRACT_PUBMED_16713295}}


==Disease==
==Disease==
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[[Category: Titin]]
[[Category: Titin]]
[[Category: Z1z2]]
[[Category: Z1z2]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:58:17 2008''

Revision as of 21:58, 28 July 2008

File:2f8v.png

Template:STRUCTURE 2f8v

Structure of full length telethonin in complex with the N-terminus of titin

Template:ABSTRACT PUBMED 16713295

Disease

Known disease associated with this structure: Cardiomyopathy, dilated, 1N OMIM:[604488], Muscular dystrophy, limb-girdle, type 2G OMIM:[604488]

About this Structure

2F8V is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Evidence for a dimeric assembly of two titin/telethonin complexes induced by the telethonin C-terminus., Pinotsis N, Petoukhov M, Lange S, Svergun D, Zou P, Gautel M, Wilmanns M, J Struct Biol. 2006 Aug;155(2):239-50. Epub 2006 Apr 27. PMID:16713295

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