2f8x: Difference between revisions

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[[Image:2f8x.gif|left|200px]]
{{Seed}}
[[Image:2f8x.png|left|200px]]


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{{STRUCTURE_2f8x|  PDB=2f8x  |  SCENE=  }}  
{{STRUCTURE_2f8x|  PDB=2f8x  |  SCENE=  }}  


'''Crystal structure of activated Notch, CSL and MAML on HES-1 promoter DNA sequence'''
===Crystal structure of activated Notch, CSL and MAML on HES-1 promoter DNA sequence===




==Overview==
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Notch receptors transduce essential developmental signals between neighboring cells by forming a complex that leads to transcription of target genes upon activation. We report here the crystal structure of a Notch transcriptional activation complex containing the ankyrin domain of human Notch1 (ANK), the transcription factor CSL on cognate DNA, and a polypeptide from the coactivator Mastermind-like-1 (MAML-1). Together, CSL and ANK create a groove to bind the MAML-1 polypeptide as a kinked, 70 A helix. The composite binding surface likely restricts the recruitment of MAML proteins to promoters on which Notch:CSL complexes have been preassembled, ensuring tight transcriptional control of Notch target genes.
The line below this paragraph, {{ABSTRACT_PUBMED_16530044}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16530044}}


==About this Structure==
==About this Structure==
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[[Category: Notch]]
[[Category: Notch]]
[[Category: Rel-homology region]]
[[Category: Rel-homology region]]
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