2fau: Difference between revisions

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[[Image:2fau.gif|left|200px]]
{{Seed}}
[[Image:2fau.png|left|200px]]


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{{STRUCTURE_2fau|  PDB=2fau  |  SCENE=  }}  
{{STRUCTURE_2fau|  PDB=2fau  |  SCENE=  }}  


'''Crystal structure of human vps26'''
===Crystal structure of human vps26===




==Overview==
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The mammalian retromer complex consists of SNX1, SNX2, Vps26, Vps29 and Vps35, and retrieves lysosomal enzyme receptors from endosomes to the trans-Golgi network. The structure of human Vps26A at 2.1-A resolution reveals two curved beta-sandwich domains connected by a polar core and a flexible linker. Vps26 has an unpredicted structural relationship to arrestins. The Vps35-binding site on Vps26 maps to a mobile loop spanning residues 235-246, near the tip of the C-terminal domain. The loop is phylogenetically conserved and provides a mechanism for Vps26 integration into the complex that leaves the rest of the structure free for engagements with membranes and for conformational changes. Hydrophobic residues and a glycine in this loop are required for integration into the retromer complex and endosomal localization of human Vps26, and for the function of yeast Vps26 in carboxypeptidase Y sorting.
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{{ABSTRACT_PUBMED_16732284}}


==About this Structure==
==About this Structure==
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[[Category: Arrestin]]
[[Category: Arrestin]]
[[Category: Retromer]]
[[Category: Retromer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:43:31 2008''

Revision as of 00:43, 29 July 2008

File:2fau.png

Template:STRUCTURE 2fau

Crystal structure of human vps26

Template:ABSTRACT PUBMED 16732284

About this Structure

2FAU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The retromer subunit Vps26 has an arrestin fold and binds Vps35 through its C-terminal domain., Shi H, Rojas R, Bonifacino JS, Hurley JH, Nat Struct Mol Biol. 2006 Jun;13(6):540-8. Epub 2006 May 28. PMID:16732284

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