2fcw: Difference between revisions

Line 1:

[[Image:2fcw.~~gif~~|left|200px]]

[[Image:2fcw.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Structure of a Complex Between the Pair of the LDL Receptor Ligand-Binding Modules 3-4 and the Receptor Associated Protein (RAP).~~'''~~

===Structure of a Complex Between the Pair of the LDL Receptor Ligand-Binding Modules 3-4 and the Receptor Associated Protein (RAP).===

~~==Overview==~~

<!--

~~Proteins of~~ the ~~low-density lipoprotein receptor (LDLR) family are remarkable in their ability~~ to ~~bind an extremely diverse range of protein and lipoprotein ligands, yet~~ the ~~basis for ligand recognition is poorly understood~~. ~~Here, we report the 1~~.26 A X-ray structure of a complex between a two-module region of the ligand binding domain of the LDLR and the third domain of RAP, an escort protein for LDLR family members. The RAP domain forms a three-helix bundle with two docking sites, ~~one for each LDLR module. The mode of recognition at each site~~ is ~~virtually identical: three conserved, calcium-coordinating acidic residues from each LDLR module encircle a lysine side chain protruding from~~ the ~~second helix of RAP~~. ~~This metal~~-dependent mode of electrostatic recognition, together with avidity effects resulting from the use of multiple sites, represents a general binding strategy likely to apply in the binding of other basic ligands to LDLR family proteins.

The line below this paragraph, {{ABSTRACT_PUBMED_16630895}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16630895 is the PubMed ID number.

-->

==Disease==

Line 33:

Line 37:

[[Category: Protein-protein complex]]

[[Category: Rap]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4~~ 03:44:51 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:55:42 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:2fcw.gif|left|200px]]
+{{Seed}}
+[[Image:2fcw.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2fcw|  PDB=2fcw  |  SCENE=  }}
-'''Structure of a Complex Between the Pair of the LDL Receptor Ligand-Binding Modules 3-4 and the Receptor Associated Protein (RAP).'''
+===Structure of a Complex Between the Pair of the LDL Receptor Ligand-Binding Modules 3-4 and the Receptor Associated Protein (RAP).===
-==Overview==
+<!--
-Proteins of the low-density lipoprotein receptor (LDLR) family are remarkable in their ability to bind an extremely diverse range of protein and lipoprotein ligands, yet the basis for ligand recognition is poorly understood. Here, we report the 1.26 A X-ray structure of a complex between a two-module region of the ligand binding domain of the LDLR and the third domain of RAP, an escort protein for LDLR family members. The RAP domain forms a three-helix bundle with two docking sites, one for each LDLR module. The mode of recognition at each site is virtually identical: three conserved, calcium-coordinating acidic residues from each LDLR module encircle a lysine side chain protruding from the second helix of RAP. This metal-dependent mode of electrostatic recognition, together with avidity effects resulting from the use of multiple sites, represents a general binding strategy likely to apply in the binding of other basic ligands to LDLR family proteins.
+The line below this paragraph, {{ABSTRACT_PUBMED_16630895}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16630895 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16630895}}
 ==Disease==
@@ Line 33: / Line 37: @@
 [[Category: Protein-protein complex]]
 [[Category: Rap]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:44:51 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:55:42 2008''