2fda: Difference between revisions

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~~'''~~Crystal Structure of the Catalytic Domain of Human Coagulation Factor XIa in Complex with alpha-Ketothiazole Arginine Derived Ligand~~'''~~

===Crystal Structure of the Catalytic Domain of Human Coagulation Factor XIa in Complex with alpha-Ketothiazole Arginine Derived Ligand===

~~==Overview==~~

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~~Using an alpha-ketothiazole arginine moiety as a key recognition element~~, ~~a series of small peptidomimetic molecules was designed and synthesized~~, ~~and their co-crystal structures with factor XIa were studied in an effort~~ to ~~develop smaller~~, ~~less peptidic inhibitors as antithrombotic agents~~.

The line below this paragraph, {{ABSTRACT_PUBMED_16524727}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16524727 is the PubMed ID number.

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==Disease==

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==Reference==

Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine., Deng H, Bannister TD, Jin L, Babine RE, Quinn J, Nagafuji P, Celatka CA, Lin J, Lazarova TI, Rynkiewicz MJ, Bibbins F, Pandey P, Gorga J, Meyers HV, Abdel-Meguid SS, Strickler JE, Bioorg Med Chem Lett. 2006 Jun 1;16(11):3049-54. Epub 2006 Mar 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16524727 16524727]

Mutation of surface residues to promote crystallization of activated factor XI as a complex with benzamidine: an essential step for the iterative structure-based design of factor XI inhibitors., Jin L, Pandey P, Babine RE, Weaver DT, Abdel-Meguid SS, Strickler JE, Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1418-25. Epub 2005, Sep 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16204896 16204896]

[[Category: Coagulation factor XIa]]

[[Category: Homo sapiens]]

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[[Category: Fxia]]

[[Category: Inhibitor]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4~~ 03:45:24 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:48:13 2008''

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-[[Image:2fda.gif|left|200px]]
+{{Seed}}
+[[Image:2fda.png|left|200px]]
 <!--
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 {{STRUCTURE_2fda|  PDB=2fda  |  SCENE=  }}
-'''Crystal Structure of the Catalytic Domain of Human Coagulation Factor XIa in Complex with alpha-Ketothiazole Arginine Derived Ligand'''
+===Crystal Structure of the Catalytic Domain of Human Coagulation Factor XIa in Complex with alpha-Ketothiazole Arginine Derived Ligand===
-==Overview==
+<!--
-Using an alpha-ketothiazole arginine moiety as a key recognition element, a series of small peptidomimetic molecules was designed and synthesized, and their co-crystal structures with factor XIa were studied in an effort to develop smaller, less peptidic inhibitors as antithrombotic agents.
+The line below this paragraph, {{ABSTRACT_PUBMED_16524727}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16524727 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16524727}}
 ==Disease==
@@ Line 23: / Line 27: @@
 ==Reference==
 Synthesis, SAR exploration, and X-ray crystal structures of factor XIa inhibitors containing an alpha-ketothiazole arginine., Deng H, Bannister TD, Jin L, Babine RE, Quinn J, Nagafuji P, Celatka CA, Lin J, Lazarova TI, Rynkiewicz MJ, Bibbins F, Pandey P, Gorga J, Meyers HV, Abdel-Meguid SS, Strickler JE, Bioorg Med Chem Lett. 2006 Jun 1;16(11):3049-54. Epub 2006 Mar 9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16524727 16524727]
+Mutation of surface residues to promote crystallization of activated factor XI as a complex with benzamidine: an essential step for the iterative structure-based design of factor XI inhibitors., Jin L, Pandey P, Babine RE, Weaver DT, Abdel-Meguid SS, Strickler JE, Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1418-25. Epub 2005, Sep 28. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16204896 16204896]
 [[Category: Coagulation factor XIa]]
 [[Category: Homo sapiens]]
@@ Line 34: / Line 40: @@
 [[Category: Fxia]]
 [[Category: Inhibitor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:45:24 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:48:13 2008''