2fdd: Difference between revisions

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[[Image:2fdd.gif|left|200px]]
{{Seed}}
[[Image:2fdd.png|left|200px]]


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{{STRUCTURE_2fdd|  PDB=2fdd  |  SCENE=  }}  
{{STRUCTURE_2fdd|  PDB=2fdd  |  SCENE=  }}  


'''Crystal structure of HIV protease D545701 bound with GW0385'''
===Crystal structure of HIV protease D545701 bound with GW0385===




==Overview==
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A novel series of P1 modified HIV protease inhibitors was synthesized and evaluated for in vitro antiviral activity against wild-type virus and protease inhibitor-resistant viruses. Optimization of the P1 moiety resulted in compounds with femtomolar enzyme activities and cellular antiviral activities in the low nanomolar range culminating in the identification of clinical candidate GW0385.
The line below this paragraph, {{ABSTRACT_PUBMED_16458505}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16458505 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16458505}}


==About this Structure==
==About this Structure==
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[[Category: Hiv protease]]
[[Category: Hiv protease]]
[[Category: Inhibitor]]
[[Category: Inhibitor]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:45:31 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:09:36 2008''