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| {{STRUCTURE_2fh5| PDB=2fh5 | SCENE= }} | | {{STRUCTURE_2fh5| PDB=2fh5 | SCENE= }} |
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| '''The Structure of the Mammalian SRP Receptor'''
| | ===The Structure of the Mammalian SRP Receptor=== |
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| ==Overview==
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| The eukaryotic signal recognition particle (SRP) and its receptor (SR) play a central role in co-translational targeting of secretory and membrane proteins to the endoplasmic reticulum. The SR is a heterodimeric complex assembled by the two GTPases SRalpha and SRbeta, which is membrane-anchored. Here we present the 2.45-A structure of mammalian SRbeta in its Mg2+ GTP-bound state in complex with the minimal binding domain of SRalpha termed SRX. SRbeta is a member of the Ras-GTPase superfamily closely related to Arf and Sar1, while SRX belongs to the SNARE-like superfamily with a fold also known as longin domain. SRX binds to the P loop and the switch regions of SRbeta-GTP. The binding mode and structural similarity with other GTPase-effector complexes suggests a co-GAP (GTPase-activating protein) function for SRX. Comparison with the homologous yeast structure and other longin domains reveals a conserved adjustable hydrophobic surface within SRX which is of central importance for the SRbeta-GTP:SRX interface. A helix swap in SRX results in the formation of a dimer in the crystal structure. Based on structural conservation we present the SRbeta-GTP:SRX structure as a prototype for conserved interactions in a variety of GTPase regulated targeting events occurring at endomembranes. | | The line below this paragraph, {{ABSTRACT_PUBMED_16439358}}, adds the Publication Abstract to the page |
| | (as it appears on PubMed at http://www.pubmed.gov), where 16439358 is the PubMed ID number. |
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| | {{ABSTRACT_PUBMED_16439358}} |
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| ==About this Structure== | | ==About this Structure== |
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| [[Category: Signal recognition particle receptor]] | | [[Category: Signal recognition particle receptor]] |
| [[Category: X-ray structure]] | | [[Category: X-ray structure]] |
| ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 03:53:24 2008'' | | |
| | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:03:09 2008'' |
