2fif: Difference between revisions

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[[Image:2fif.gif|left|200px]]
{{Seed}}
[[Image:2fif.png|left|200px]]


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{{STRUCTURE_2fif|  PDB=2fif  |  SCENE=  }}  
{{STRUCTURE_2fif|  PDB=2fif  |  SCENE=  }}  


'''Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin'''
===Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin===




==Overview==
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Rabex-5 is an exchange factor for Rab5, a master regulator of endosomal trafficking. Rabex-5 binds monoubiquitin, undergoes covalent ubiquitination and contains an intrinsic ubiquitin ligase activity, all of which require an N-terminal A20 zinc finger followed immediately by a helix. The structure of the N-terminal portion of Rabex-5 bound to ubiquitin at 2.5-A resolution shows that Rabex-5-ubiquitin interactions occur at two sites. The first site is a new type of ubiquitin-binding domain, an inverted ubiquitin-interacting motif, which binds with approximately 29-microM affinity to the canonical Ile44 hydrophobic patch on ubiquitin. The second is a diaromatic patch on the A20 zinc finger, which binds with approximately 22-microM affinity to a polar region centered on Asp58 of ubiquitin. The A20 zinc-finger diaromatic patch mediates ubiquitin-ligase activity by directly recruiting a ubiquitin-loaded ubiquitin-conjugating enzyme.
The line below this paragraph, {{ABSTRACT_PUBMED_16462746}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16462746}}


==About this Structure==
==About this Structure==
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[[Category: Helix]]
[[Category: Helix]]
[[Category: Zinc finger]]
[[Category: Zinc finger]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:56:09 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 22:03:41 2008''

Revision as of 19:03, 28 July 2008

File:2fif.png

Template:STRUCTURE 2fif

Crystal Structure of a Bovine Rabex-5 fragment complexed with ubiquitin

Template:ABSTRACT PUBMED 16462746

About this Structure

2FIF is a Protein complex structure of sequences from Bos taurus. Full crystallographic information is available from OCA.

Reference

Structural basis for ubiquitin recognition and autoubiquitination by Rabex-5., Lee S, Tsai YC, Mattera R, Smith WJ, Kostelansky MS, Weissman AM, Bonifacino JS, Hurley JH, Nat Struct Mol Biol. 2006 Mar;13(3):264-71. Epub 2006 Feb 5. PMID:16462746

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