2fjt: Difference between revisions

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[[Image:2fjt.gif|left|200px]]
{{Seed}}
[[Image:2fjt.png|left|200px]]


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{{STRUCTURE_2fjt|  PDB=2fjt  |  SCENE=  }}  
{{STRUCTURE_2fjt|  PDB=2fjt  |  SCENE=  }}  


'''Adenylyl cyclase class iv from Yersinia pestis'''
===Adenylyl cyclase class iv from Yersinia pestis===




==Overview==
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The crystal structure of the class IV adenylyl cyclase (AC) from Yersinia pestis (Yp) is reported at 1.9 A resolution. The class IV AC fold is distinct from the previously described folds for class II and class III ACs. The dimeric AC-IV folds into an antiparallel eight-stranded barrel whose connectivity has been seen in only three previous structures: yeast RNA triphosphatase and two proteins of unknown function from Pyrococcus furiosus and Vibrio parahaemolyticus. Eight highly conserved ionic residues E10, E12, K14, R63, K76, K111, D126, and E136 lie in the barrel core and form the likely binding sites for substrate and divalent cations. A phosphate ion is observed bound to R63, K76, K111, and R113 near the center of the conserved cluster. Unlike the AC-II and AC-III active sites that utilize two-Asp motifs for cation binding, the AC-IV active site is relatively enriched in glutamate and features an ExE motif as its most conserved element. Homologs of Y. pestis AC-IV, including human thiamine triphosphatase, span the three kingdoms of life and delineate an ancient family of phosphonucleotide processing enzymes.
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{{ABSTRACT_PUBMED_16905149}}


==About this Structure==
==About this Structure==
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[[Category: Cyclase]]
[[Category: Cyclase]]
[[Category: Dimer]]
[[Category: Dimer]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 03:58:52 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:33:49 2008''

Revision as of 16:33, 27 July 2008

File:2fjt.png

Template:STRUCTURE 2fjt

Adenylyl cyclase class iv from Yersinia pestis

Template:ABSTRACT PUBMED 16905149

About this Structure

2FJT is a Single protein structure of sequence from Yersinia pestis. Full crystallographic information is available from OCA.

Reference

Structure of the class IV adenylyl cyclase reveals a novel fold., Gallagher DT, Smith NN, Kim SK, Heroux A, Robinson H, Reddy PT, J Mol Biol. 2006 Sep 8;362(1):114-22. Epub 2006 Aug 14. PMID:16905149

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