2fl2: Difference between revisions

From Proteopedia
Jump to navigationJump to search
OCA (talk | contribs)
No edit summary
OCA (talk | contribs)
No edit summary
Line 1: Line 1:
[[Image:2fl2.gif|left|200px]]
{{Seed}}
[[Image:2fl2.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2fl2|  PDB=2fl2  |  SCENE=  }}  
{{STRUCTURE_2fl2|  PDB=2fl2  |  SCENE=  }}  


'''crystal structure of KSP in complex with inhibitor 19'''
===crystal structure of KSP in complex with inhibitor 19===




==Overview==
<!--
The evolution of 2,4-diaryl-2,5-dihydropyrroles as inhibitors of KSP is described. Introduction of basic amide and urea moieties to the dihydropyrrole nucleus enhanced potency and aqueous solubility, simultaneously, and provided compounds that caused mitotic arrest of A2780 human ovarian carcinoma cells with EC(50)s&lt;10nM. Ancillary hERG activity was evaluated for this series of inhibitors.
The line below this paragraph, {{ABSTRACT_PUBMED_16439123}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16439123 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_16439123}}


==About this Structure==
==About this Structure==
Line 25: Line 29:
[[Category: Ksp]]
[[Category: Ksp]]
[[Category: Ksp-inhibitor complex]]
[[Category: Ksp-inhibitor complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:01:07 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:18:01 2008''