2fov: Difference between revisions

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[[Image:2fov.gif|left|200px]]
{{Seed}}
[[Image:2fov.png|left|200px]]


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{{STRUCTURE_2fov|  PDB=2fov  |  SCENE=  }}  
{{STRUCTURE_2fov|  PDB=2fov  |  SCENE=  }}  


'''Human Carbonic Anhydrase II complexed with two-prong inhibitors'''
===Human Carbonic Anhydrase II complexed with two-prong inhibitors===




==Overview==
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The atomic-resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors are reported. Each inhibitor contains a benzenesulfonamide prong and a cupric iminodiacetate (IDA-Cu(2+)) prong separated by linkers of different lengths and compositions. The ionized NH(-) group of each benzenesulfonamide coordinates to the active site Zn(2+) ion; the IDA-Cu(2+) prong of the tightest-binding inhibitor, BR30, binds to H64 of CAII and H200 of CAI. This work provides the first evidence verifying the structural basis of nanomolar affinity measured for two-prong inhibitors targeting the carbonic anhydrases.
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{{ABSTRACT_PUBMED_16506782}}


==Disease==
==Disease==
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[[Category: Lyase]]
[[Category: Lyase]]
[[Category: Zinc]]
[[Category: Zinc]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:09:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:55:13 2008''

Revision as of 13:55, 28 July 2008

File:2fov.png

Template:STRUCTURE 2fov

Human Carbonic Anhydrase II complexed with two-prong inhibitors

Template:ABSTRACT PUBMED 16506782

Disease

Known disease associated with this structure: Osteopetrosis, autosomal recessive 3, with renal tubular acidosis OMIM:[611492]

About this Structure

2FOV is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors reveal the molecular basis of high affinity., Jude KM, Banerjee AL, Haldar MK, Manokaran S, Roy B, Mallik S, Srivastava DK, Christianson DW, J Am Chem Soc. 2006 Mar 8;128(9):3011-8. PMID:16506782

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