2fqn: Difference between revisions

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[[Image:2fqn.~~gif~~|left|200px]]

[[Image:2fqn.png|left|200px]]

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~~'''~~Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site~~'''~~

===Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site===

~~==Overview==~~

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The ~~decoding A site of the small ribosomal subunit is an RNA molecular switch~~, ~~which monitors codon-anticodon interactions to guarantee translation fidelity. We have solved~~ the crystal structure of an RNA fragment containing two Homo sapiens cytoplasmic A sites. Each of the two A sites presents a different conformational state. In one state, adenines A1492 and A1493 are fully bulged-out with C1409 forming a wobble-like pair to ~~A1491. In~~ the ~~second state, adenines A1492 and A1493 form non-Watson-Crick pairs with C1409 and G1408, respectively while A1491 bulges out. The first state of the eukaryotic A site is, thus, basically the same~~ as ~~in the bacterial A site with bulging A1492 and A1493~~. ~~It is the state used for recognition of the codon/anticodon complex~~. ~~On the contrary~~, ~~the second state of the H.sapiens cytoplasmic A site~~ is ~~drastically different from any of those observed for~~ the ~~bacterial A site without bulging A1492 and A1493~~.

The line below this paragraph, {{ABSTRACT_PUBMED_16452297}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16452297 is the PubMed ID number.

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==About this Structure==

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[[Category: Rna duplex]]

[[Category: Rrna]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 04~~:12:20 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:32:09 2008''

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-[[Image:2fqn.gif|left|200px]]
+{{Seed}}
+[[Image:2fqn.png|left|200px]]
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 {{STRUCTURE_2fqn|  PDB=2fqn  |  SCENE=  }}
-'''Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site'''
+===Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding A site===
-==Overview==
+<!--
-The decoding A site of the small ribosomal subunit is an RNA molecular switch, which monitors codon-anticodon interactions to guarantee translation fidelity. We have solved the crystal structure of an RNA fragment containing two Homo sapiens cytoplasmic A sites. Each of the two A sites presents a different conformational state. In one state, adenines A1492 and A1493 are fully bulged-out with C1409 forming a wobble-like pair to A1491. In the second state, adenines A1492 and A1493 form non-Watson-Crick pairs with C1409 and G1408, respectively while A1491 bulges out. The first state of the eukaryotic A site is, thus, basically the same as in the bacterial A site with bulging A1492 and A1493. It is the state used for recognition of the codon/anticodon complex. On the contrary, the second state of the H.sapiens cytoplasmic A site is drastically different from any of those observed for the bacterial A site without bulging A1492 and A1493.
+The line below this paragraph, {{ABSTRACT_PUBMED_16452297}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16452297 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16452297}}
 ==About this Structure==
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 [[Category: Rna duplex]]
 [[Category: Rrna]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:12:20 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 01:32:09 2008''