2nll: Difference between revisions

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[[Image:2nll.gif|left|200px]]<br />

[[Image:2nll.gif|left|200px]]<br /><applet load="2nll" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="2nll" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="2nll, resolution 1.900Å" />

'''RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA'''<br />

==Overview==

Nuclear receptor heterodimers recognize response elements composed of two, direct repeats of the consensus sequence 5'-AGGTCA-3' separated by one to, five base pairs. The 1.9 A crystal structure of the complex formed by the, DNA-binding domains of the 9-cis retinoic acid receptor and thyroid, hormone receptor bound to a thyroid-response element shows that the, subunits interact through a DNA-supported interface involving the, carboxy-terminal extension of the DNA-binding domain of the thyroid, hormone receptor. The stereochemistry suggests a mechanism by which, heterodimers recognize the inter-half-site spacing between direct repeats.

Nuclear receptor heterodimers recognize response elements composed of two direct repeats of the consensus sequence 5'-AGGTCA-3' separated by one to five base pairs. The 1.9 A crystal structure of the complex formed by the DNA-binding domains of the 9-cis retinoic acid receptor and thyroid hormone receptor bound to a thyroid-response element shows that the subunits interact through a DNA-supported interface involving the carboxy-terminal extension of the DNA-binding domain of the thyroid hormone receptor. The stereochemistry suggests a mechanism by which heterodimers recognize the inter-half-site spacing between direct repeats.

==Disease==

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==About this Structure==

2NLL is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2NLL OCA].

2NLL is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLL OCA].

==Reference==

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[[Category: Homo sapiens]]

[[Category: Protein complex]]

[[Category: Evans, R.M.]]

[[Category: Evans, R M.]]

[[Category: Perlmann, T.]]

[[Category: Rastinejad, F.]]

[[Category: Sigler, P.B.]]

[[Category: Sigler, P B.]]

[[Category: ZN]]

[[Category: alternative splicing]]

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[[Category: zinc- finger]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 22~~:59:~~10 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:08:15 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2nll.gif|left|200px]]<br />
+[[Image:2nll.gif|left|200px]]<br /><applet load="2nll" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="2nll" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="2nll, resolution 1.900&Aring;" />
 '''RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA'''<br />
 ==Overview==
-Nuclear receptor heterodimers recognize response elements composed of two, direct repeats of the consensus sequence 5'-AGGTCA-3' separated by one to, five base pairs. The 1.9 A crystal structure of the complex formed by the, DNA-binding domains of the 9-cis retinoic acid receptor and thyroid, hormone receptor bound to a thyroid-response element shows that the, subunits interact through a DNA-supported interface involving the, carboxy-terminal extension of the DNA-binding domain of the thyroid, hormone receptor. The stereochemistry suggests a mechanism by which, heterodimers recognize the inter-half-site spacing between direct repeats.
+Nuclear receptor heterodimers recognize response elements composed of two direct repeats of the consensus sequence 5'-AGGTCA-3' separated by one to five base pairs. The 1.9 A crystal structure of the complex formed by the DNA-binding domains of the 9-cis retinoic acid receptor and thyroid hormone receptor bound to a thyroid-response element shows that the subunits interact through a DNA-supported interface involving the carboxy-terminal extension of the DNA-binding domain of the thyroid hormone receptor. The stereochemistry suggests a mechanism by which heterodimers recognize the inter-half-site spacing between direct repeats.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-NLL is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2NLL OCA].
+NLL is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NLL OCA].
 ==Reference==
@@ Line 17: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Protein complex]]
-[[Category: Evans, R.M.]]
+[[Category: Evans, R M.]]
 [[Category: Perlmann, T.]]
 [[Category: Rastinejad, F.]]
-[[Category: Sigler, P.B.]]
+[[Category: Sigler, P B.]]
 [[Category: ZN]]
 [[Category: alternative splicing]]
@@ Line 30: / Line 29: @@
 [[Category: zinc- finger]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 22:59:10 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:08:15 2008''