2fum: Difference between revisions

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[[Image:2fum.~~gif~~|left|200px]]

[[Image:2fum.png|left|200px]]

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~~'''~~Catalytic domain of protein kinase PknB from Mycobacterium tuberculosis in complex with mitoxantrone~~'''~~

===Catalytic domain of protein kinase PknB from Mycobacterium tuberculosis in complex with mitoxantrone===

~~==Overview==~~

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~~Mycobacterium tuberculosis PknB is an essential receptor-like protein kinase involved in cell growth control. Here, we demonstrate that mitoxantrone~~, ~~an anthraquinone derivative used in cancer therapy~~, ~~is a PknB inhibitor capable of preventing mycobacterial growth. The structure of~~ the ~~complex reveals that mitoxantrone partially occupies~~ the ~~adenine-binding pocket in PknB~~, ~~providing a framework for~~ the ~~design of compounds with potential therapeutic applications~~. ~~PknB crystallizes as a 'back~~-to-back' homodimer identical to those observed in other structures of PknB in complex with ATP analogs. This organization resembles that of the RNA-dependent protein kinase PKR, suggesting a mechanism for kinase activation in mycobacteria.

The line below this paragraph, {{ABSTRACT_PUBMED_16674948}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16674948 is the PubMed ID number.

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==About this Structure==

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[[Category: Wehenkel, A.]]

[[Category: Protein kinase-inhibitor complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 04~~:19:45 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:30:58 2008''

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-[[Image:2fum.gif|left|200px]]
+{{Seed}}
+[[Image:2fum.png|left|200px]]
 <!--
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 {{STRUCTURE_2fum|  PDB=2fum  |  SCENE=  }}
-'''Catalytic domain of protein kinase PknB from Mycobacterium tuberculosis in complex with mitoxantrone'''
+===Catalytic domain of protein kinase PknB from Mycobacterium tuberculosis in complex with mitoxantrone===
-==Overview==
+<!--
-Mycobacterium tuberculosis PknB is an essential receptor-like protein kinase involved in cell growth control. Here, we demonstrate that mitoxantrone, an anthraquinone derivative used in cancer therapy, is a PknB inhibitor capable of preventing mycobacterial growth. The structure of the complex reveals that mitoxantrone partially occupies the adenine-binding pocket in PknB, providing a framework for the design of compounds with potential therapeutic applications. PknB crystallizes as a 'back-to-back' homodimer identical to those observed in other structures of PknB in complex with ATP analogs. This organization resembles that of the RNA-dependent protein kinase PKR, suggesting a mechanism for kinase activation in mycobacteria.
+The line below this paragraph, {{ABSTRACT_PUBMED_16674948}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16674948 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16674948}}
 ==About this Structure==
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 [[Category: Wehenkel, A.]]
 [[Category: Protein kinase-inhibitor complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:19:45 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 13:30:58 2008''