2fvn: Difference between revisions

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[[Image:2fvn.~~jpg~~|left|200px]]

[[Image:2fvn.png|left|200px]]

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~~'''~~The fibrillar tip complex of the Afa/Dr adhesins from pathogen E. coli displays synergistic binding to 5 1 and v 3 integrins~~'''~~

===The fibrillar tip complex of the Afa/Dr adhesins from pathogen E. coli displays synergistic binding to 5 1 and v 3 integrins===

~~==Overview==~~

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~~Afa/Dr family of adhesins are produced by pathogenic Escherichia coli strains that are especially prevalent in chronic diarrhoeal and recurrent urinary tract infections. Most notably~~, ~~they are found in up~~ to ~~50% of cystitis cases in children and 30% of pyelonephritis in pregnant women~~. ~~Afa/Dr adhesins are capped surface fibrils that mediate recognition of the host and subsequent bacterial internalization~~. ~~Using the newly solved three-dimensional structure of the minimal invasive complex (AfaDE~~) ~~combined with biochemical and cellular assays~~, ~~we reveal~~ the ~~architecture of the fibrillar cap and identify a novel mode of synergistic integrin recognition~~.

The line below this paragraph, {{ABSTRACT_PUBMED_16965519}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16965519 is the PubMed ID number.

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==About this Structure==

2FVN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVN OCA].

2FVN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVN OCA].

==Reference==

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[[Category: Fibrillar]]

[[Category: Integrin-binding]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 04~~:21:30 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:21:06 2008''

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-[[Image:2fvn.jpg|left|200px]]
+{{Seed}}
+[[Image:2fvn.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2fvn|  PDB=2fvn  |  SCENE=  }}
-'''The fibrillar tip complex of the Afa/Dr adhesins from pathogen E. coli displays synergistic binding to 5 1 and v 3 integrins'''
+===The fibrillar tip complex of the Afa/Dr adhesins from pathogen E. coli displays synergistic binding to 5 1 and v 3 integrins===
-==Overview==
+<!--
-Afa/Dr family of adhesins are produced by pathogenic Escherichia coli strains that are especially prevalent in chronic diarrhoeal and recurrent urinary tract infections. Most notably, they are found in up to 50% of cystitis cases in children and 30% of pyelonephritis in pregnant women. Afa/Dr adhesins are capped surface fibrils that mediate recognition of the host and subsequent bacterial internalization. Using the newly solved three-dimensional structure of the minimal invasive complex (AfaDE) combined with biochemical and cellular assays, we reveal the architecture of the fibrillar cap and identify a novel mode of synergistic integrin recognition.
+The line below this paragraph, {{ABSTRACT_PUBMED_16965519}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16965519 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16965519}}
 ==About this Structure==
-FVN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVN OCA].
+FVN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FVN OCA].
 ==Reference==
@@ Line 34: / Line 38: @@
 [[Category: Fibrillar]]
 [[Category: Integrin-binding]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:21:30 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:21:06 2008''