2fy9: Difference between revisions

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[[Image:2fy9.gif|left|200px]]
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[[Image:2fy9.png|left|200px]]


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{{STRUCTURE_2fy9|  PDB=2fy9  |  SCENE=  }}  
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'''Solution Structure of the N-Terminal DNA Recognition Domain of the Bacillus Subtilis Transcription-State Regulator ABH'''
===Solution Structure of the N-Terminal DNA Recognition Domain of the Bacillus Subtilis Transcription-State Regulator ABH===




==Overview==
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Understanding the molecular mechanisms of transition state regulator proteins is critical, since they play a pivotal role in the ability of bacteria to cope with changing environments. Although much effort has focused on their genetic characterization, little is known about their structural and functional conservation. Here we present the high resolution NMR solution structure of the N-terminal domain of the Bacillus subtilis transition state regulator Abh (AbhN), only the second such structure to date. We then compare AbhN to the N-terminal DNA-binding domain of B. subtilis AbrB (AbrBN). This is the first such comparison between two AbrB-like transition state regulators. AbhN and AbrBN are very similar, suggesting a common structural basis for their DNA binding. However, we also note subtle variances between the AbhN and AbrBN structures, which may play important roles in DNA target specificity. The results of accompanying in vitro DNA-binding studies serve to highlight binding differences between the two proteins.
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{{ABSTRACT_PUBMED_16702211}}


==About this Structure==
==About this Structure==
2FY9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FY9 OCA].  
2FY9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2FY9 OCA].  


==Reference==
==Reference==
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[[Category: N-terminal dna-binding domain]]
[[Category: N-terminal dna-binding domain]]
[[Category: Transition state regulator]]
[[Category: Transition state regulator]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:26:33 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:06:15 2008''

Revision as of 01:06, 29 July 2008

File:2fy9.png

Template:STRUCTURE 2fy9

Solution Structure of the N-Terminal DNA Recognition Domain of the Bacillus Subtilis Transcription-State Regulator ABH

Template:ABSTRACT PUBMED 16702211

About this Structure

2FY9 is a Single protein structure of sequence from Bacillus subtilis. Full experimental information is available from OCA.

Reference

NMR structure of AbhN and comparison with AbrBN: FIRST insights into the DNA binding promiscuity and specificity of AbrB-like transition state regulator proteins., Bobay BG, Mueller GA, Thompson RJ, Murzin AG, Venters RA, Strauch MA, Cavanagh J, J Biol Chem. 2006 Jul 28;281(30):21399-409. Epub 2006 May 15. PMID:16702211

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