2fym: Difference between revisions

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[[Image:2fym.gif|left|200px]]
{{Seed}}
[[Image:2fym.png|left|200px]]


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{{STRUCTURE_2fym|  PDB=2fym  |  SCENE=  }}  
{{STRUCTURE_2fym|  PDB=2fym  |  SCENE=  }}  


'''Crystal structure of E. coli enolase complexed with the minimal binding segment of RNase E.'''
===Crystal structure of E. coli enolase complexed with the minimal binding segment of RNase E.===




==Overview==
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In Escherichia coli, the glycolytic enzyme enolase is a component of the RNA degradosome, which is an RNase E mediated assembly involved in RNA processing and transcript turnover. The recruitment of enolase by the RNA degradosome has been implicated in the turnover of certain transcripts, and it is mediated by a small segment of roughly a dozen residues that lie within a natively unstructured sub-domain of RNase E. Here, we present the crystal structure of enolase in complex with its recognition site from RNase E at 1.6A resolution. A single molecule of the RNase E peptide binds asymmetrically in a conserved cleft at the interface of the enolase dimer. The recognition site is well conserved in RNase E homologues in a subfamily of the gamma-proteobacteria, including enzymes from pathogens such as Yersinia pestis, Vibrio cholera and Salmonella sp. We suggest that enolase is recruited into putative RNA degradosome machinery in these bacilli, where it plays common regulatory functions.
The line below this paragraph, {{ABSTRACT_PUBMED_16516921}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16516921}}


==About this Structure==
==About this Structure==
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[[Category: Rna degradosome]]
[[Category: Rna degradosome]]
[[Category: Rnase e]]
[[Category: Rnase e]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:27:32 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:00:38 2008''

Revision as of 08:00, 29 July 2008

File:2fym.png

Template:STRUCTURE 2fym

Crystal structure of E. coli enolase complexed with the minimal binding segment of RNase E.

Template:ABSTRACT PUBMED 16516921

About this Structure

2FYM is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Recognition of enolase in the Escherichia coli RNA degradosome., Chandran V, Luisi BF, J Mol Biol. 2006 Apr 21;358(1):8-15. Epub 2006 Feb 21. PMID:16516921

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