2fyy: Difference between revisions

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[[Image:2fyy.jpg|left|200px]]
{{Seed}}
[[Image:2fyy.png|left|200px]]


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{{STRUCTURE_2fyy|  PDB=2fyy  |  SCENE=  }}  
{{STRUCTURE_2fyy|  PDB=2fyy  |  SCENE=  }}  


'''The role of T cell receptor alpha genes in directing human MHC restriction'''
===The role of T cell receptor alpha genes in directing human MHC restriction===




==Overview==
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The underlying generic properties of alphabeta TCRs that control MHC restriction remain largely unresolved. To investigate MHC restriction, we have examined the CTL response to a viral epitope that binds promiscuously to two human leukocyte Ags (HLAs) that differ by a single amino acid at position 156. Individuals expressing either HLA-B*3501 (156Leucine) or HLA-B*3508 (156Arginine) showed a potent CTL response to the 407HPVGEADYFEY417 epitope from EBV. Interestingly, the response was characterized by highly restricted TCR beta-chain usage in both HLA-B*3501+ and HLA-B*3508+ individuals; however, this conserved TRBV9+ beta-chain was associated with distinct TCR alpha-chains depending upon the HLA-B*35 allele expressed by the virus-exposed host. Functional assays confirmed that TCR alpha-chain usage determined the HLA restriction of the CTLs. Structural studies revealed significant differences in the mobility of the peptide when bound to HLA-B*3501 or HLA-B*3508. In HLA-B*3501, the bulged section of the peptide was disordered, whereas in HLA-B*3508 the bulged epitope adopted an ordered conformation. Collectively, these data demonstrate not only that mobile MHC-bound peptides can be highly immunogenic but can also stimulate an extremely biased TCR repertoire. In addition, TCR alpha-chain usage is shown to play a critical role in controlling MHC restriction between closely related allomorphs.
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{{ABSTRACT_PUBMED_17082594}}


==About this Structure==
==About this Structure==
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[[Category: Ig domain]]
[[Category: Ig domain]]
[[Category: Mhc]]
[[Category: Mhc]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:28:15 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 23:11:49 2008''

Revision as of 20:11, 27 July 2008

File:2fyy.png

Template:STRUCTURE 2fyy

The role of T cell receptor alpha genes in directing human MHC restriction

Template:ABSTRACT PUBMED 17082594

About this Structure

2FYY is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

TCR alpha genes direct MHC restriction in the potent human T cell response to a class I-bound viral epitope., Miles JJ, Borg NA, Brennan RM, Tynan FE, Kjer-Nielsen L, Silins SL, Bell MJ, Burrows JM, McCluskey J, Rossjohn J, Burrows SR, J Immunol. 2006 Nov 15;177(10):6804-14. PMID:17082594

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