2npl: Difference between revisions

Line 1:

[[Image:2npl.gif|left|200px]]<br />

[[Image:2npl.gif|left|200px]]<br /><applet load="2npl" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="2npl" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="2npl" />

'''NMR Structure of CARD d2 Domain'''<br />

==Overview==

The coxsackievirus and adenovirus receptor (CAR) mediates entry of, coxsackievirus and adenovirus. CAR possesses an extracellular region that, is comprised of 2 immunoglobulin domains termed CAR-D1 and CAR-D2. In the, present work, the solution structure of CAR-D2, consisting of residues, 142-235 of human CAR, has been determined by NMR spectroscopy. CAR-D2 is, shown to be a beta-sandwich motif comprised of two beta-sheets, which are, stabilized by two disulfide bonds. The first beta-sheet is comprised of, beta-strands A, B, and E, and the second beta-sheet is comprised of, beta-strands C, F, and G. A relatively hydrophobic helix is found between, beta-strands C and E, which replaces beta-strand D of the classical c-type, immunoglobulin fold.

The coxsackievirus and adenovirus receptor (CAR) mediates entry of coxsackievirus and adenovirus. CAR possesses an extracellular region that is comprised of 2 immunoglobulin domains termed CAR-D1 and CAR-D2. In the present work, the solution structure of CAR-D2, consisting of residues 142-235 of human CAR, has been determined by NMR spectroscopy. CAR-D2 is shown to be a beta-sandwich motif comprised of two beta-sheets, which are stabilized by two disulfide bonds. The first beta-sheet is comprised of beta-strands A, B, and E, and the second beta-sheet is comprised of beta-strands C, F, and G. A relatively hydrophobic helix is found between beta-strands C and E, which replaces beta-strand D of the classical c-type immunoglobulin fold.

==Disease==

Line 11:

Line 10:

==About this Structure==

2NPL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2NPL OCA].

2NPL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPL OCA].

==Reference==

Line 21:

Line 20:

[[Category: coxsakievirus and adenovirus receptor]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 23~~:01:~~24 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:09:29 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:2npl.gif|left|200px]]<br />
+[[Image:2npl.gif|left|200px]]<br /><applet load="2npl" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="2npl" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="2npl" />
 '''NMR Structure of CARD d2 Domain'''<br />
 ==Overview==
-The coxsackievirus and adenovirus receptor (CAR) mediates entry of, coxsackievirus and adenovirus. CAR possesses an extracellular region that, is comprised of 2 immunoglobulin domains termed CAR-D1 and CAR-D2. In the, present work, the solution structure of CAR-D2, consisting of residues, 142-235 of human CAR, has been determined by NMR spectroscopy. CAR-D2 is, shown to be a beta-sandwich motif comprised of two beta-sheets, which are, stabilized by two disulfide bonds. The first beta-sheet is comprised of, beta-strands A, B, and E, and the second beta-sheet is comprised of, beta-strands C, F, and G. A relatively hydrophobic helix is found between, beta-strands C and E, which replaces beta-strand D of the classical c-type, immunoglobulin fold.
+The coxsackievirus and adenovirus receptor (CAR) mediates entry of coxsackievirus and adenovirus. CAR possesses an extracellular region that is comprised of 2 immunoglobulin domains termed CAR-D1 and CAR-D2. In the present work, the solution structure of CAR-D2, consisting of residues 142-235 of human CAR, has been determined by NMR spectroscopy. CAR-D2 is shown to be a beta-sandwich motif comprised of two beta-sheets, which are stabilized by two disulfide bonds. The first beta-sheet is comprised of beta-strands A, B, and E, and the second beta-sheet is comprised of beta-strands C, F, and G. A relatively hydrophobic helix is found between beta-strands C and E, which replaces beta-strand D of the classical c-type immunoglobulin fold.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-NPL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2NPL OCA].
+NPL is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2NPL OCA].
 ==Reference==
@@ Line 21: / Line 20: @@
 [[Category: coxsakievirus and adenovirus receptor]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:01:24 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:09:29 2008''