2g00: Difference between revisions

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[[Image:2g00.gif|left|200px]]
{{Seed}}
[[Image:2g00.png|left|200px]]


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{{STRUCTURE_2g00|  PDB=2g00  |  SCENE=  }}  
{{STRUCTURE_2g00|  PDB=2g00  |  SCENE=  }}  


'''Factor Xa in complex with the inhibitor 3-(6-(2'-((dimethylamino)methyl)-4-biphenylyl)-7-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl)benzamide'''
===Factor Xa in complex with the inhibitor 3-(6-(2'-((dimethylamino)methyl)-4-biphenylyl)-7-oxo-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridin-1-yl)benzamide===




==Overview==
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The bicyclic dihydropyrazolopyridinone scaffold allowed for incorporation of multiple P1 moieties with subnanomolar binding affinities for blood coagulation factor Xa. The compound 3-[6-(2'-dimethylaminomethyl-biphenyl-4-yl)-7-oxo-3-trifluoro-methyl-4,5,6 ,7-tetrahydro-pyrazolo[3,4-c]pyridine-l-yl]-benzamide 6d shows good fXa potency, selectivity, in vivo efficacy and oral bioavailability. Compound 6d was selected for further pre-clinical evaluations.
The line below this paragraph, {{ABSTRACT_PUBMED_16963264}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16963264 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16963264}}


==About this Structure==
==About this Structure==
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[[Category: Protein inhibitor complex]]
[[Category: Protein inhibitor complex]]
[[Category: Serine protease]]
[[Category: Serine protease]]
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