2g0k: Difference between revisions

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[[Image:2g0k.gif|left|200px]]
{{Seed}}
[[Image:2g0k.png|left|200px]]


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{{STRUCTURE_2g0k|  PDB=2g0k  |  SCENE=  }}  
{{STRUCTURE_2g0k|  PDB=2g0k  |  SCENE=  }}  


'''Solution Structure of Neocarzinostatin Apo-Protein'''
===Solution Structure of Neocarzinostatin Apo-Protein===




==Overview==
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Neocarzinostatin (NCS) is a 1:1 complex of an enediyne chromophore (NCSChrom), non-covalently bound to an 11 kDa protein (apoNCS). We are exploring apoNCS as a generic protein system for sequestering small molecules for therapeutic applications. Here, we disclose a new flavone ligand 1 for apoNCS and present a high-resolution NMR structure of this ligand bound to apoNCS. This is the first high-resolution structure of a completely non-cognate ligand bound to the apoNCS protein. This work provides unambiguous evidence that a completely new class of ligand can bind specifically to apoNCS. Furthermore, the mode of binding is different than that of the naphthoate-based ligands, and for such a simple hydrophobic compound, the new ligand surprisingly binds specifically. This work indicates that apo-Neocarzinostatin has multiple selective and distinct binding modes for small-molecule cargo.
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(as it appears on PubMed at http://www.pubmed.gov), where 16568976 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16568976}}


==About this Structure==
==About this Structure==
2G0K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_carzinostaticus Streptomyces carzinostaticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0K OCA].  
2G0K is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptomyces_carzinostaticus Streptomyces carzinostaticus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2G0K OCA].  


==Reference==
==Reference==
Synthetic ligands for apo-neocarzinostatin., Caddick S, Muskett FW, Stoneman RG, Woolfson DN, J Am Chem Soc. 2006 Apr 5;128(13):4204-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16568976 16568976]
Synthetic ligands for apo-neocarzinostatin., Caddick S, Muskett FW, Stoneman RG, Woolfson DN, J Am Chem Soc. 2006 Apr 5;128(13):4204-5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16568976 16568976]
Solution structure of a novel chromoprotein derived from apo-neocarzinostatin and a synthetic chromophore., Urbaniak MD, Muskett FW, Finucane MD, Caddick S, Woolfson DN, Biochemistry. 2002 Oct 1;41(39):11731-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12269815 12269815]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Streptomyces carzinostaticus]]
[[Category: Streptomyces carzinostaticus]]
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[[Category: Beta sandwich]]
[[Category: Beta sandwich]]
[[Category: Igg fold]]
[[Category: Igg fold]]
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