2o39: Difference between revisions

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[[Image:2o39.gif|left|200px]]<br />

[[Image:2o39.gif|left|200px]]<br /><applet load="2o39" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="2o39" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="2o39, resolution 2.85Å" />

'''Human Adenovirus type 11 knob in complex with domains SCR1 and SCR2 of CD46 (membrane cofactor protein, MCP)'''<br />

==Overview==

Adenoviruses (Ads) are important human pathogens and valuable gene, delivery vehicles. We report here the crystal structure of the species B, Ad11 knob complexed with the Ad11-binding region of its receptor CD46. The, conformation of bound CD46 differs profoundly from its unbound state, with, the bent surface structure straightened into an elongated rod. This, mechanism of interaction is likely to be conserved among many pathogens, that target CD46 or related molecules.

Adenoviruses (Ads) are important human pathogens and valuable gene delivery vehicles. We report here the crystal structure of the species B Ad11 knob complexed with the Ad11-binding region of its receptor CD46. The conformation of bound CD46 differs profoundly from its unbound state, with the bent surface structure straightened into an elongated rod. This mechanism of interaction is likely to be conserved among many pathogens that target CD46 or related molecules.

==Disease==

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==About this Structure==

2O39 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_adenovirus_type_35p Human adenovirus type 35p] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2O39 OCA].

2O39 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_adenovirus_type_35p Human adenovirus type 35p] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O39 OCA].

==Reference==

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[[Category: Protein complex]]

[[Category: Arnberg, N.]]

[[Category: Persson, D.B.]]

[[Category: Persson, D B.]]

[[Category: Reiter, D.M.]]

[[Category: Reiter, D M.]]

[[Category: Stehle, T.]]

[[Category: CA]]

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[[Category: virus receptor complex]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 23~~:06:~~04 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:13:59 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2o39.gif|left|200px]]<br />
+[[Image:2o39.gif|left|200px]]<br /><applet load="2o39" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="2o39" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="2o39, resolution 2.85&Aring;" />
 '''Human Adenovirus type 11 knob in complex with domains SCR1 and SCR2 of CD46 (membrane cofactor protein, MCP)'''<br />
 ==Overview==
-Adenoviruses (Ads) are important human pathogens and valuable gene, delivery vehicles. We report here the crystal structure of the species B, Ad11 knob complexed with the Ad11-binding region of its receptor CD46. The, conformation of bound CD46 differs profoundly from its unbound state, with, the bent surface structure straightened into an elongated rod. This, mechanism of interaction is likely to be conserved among many pathogens, that target CD46 or related molecules.
+Adenoviruses (Ads) are important human pathogens and valuable gene delivery vehicles. We report here the crystal structure of the species B Ad11 knob complexed with the Ad11-binding region of its receptor CD46. The conformation of bound CD46 differs profoundly from its unbound state, with the bent surface structure straightened into an elongated rod. This mechanism of interaction is likely to be conserved among many pathogens that target CD46 or related molecules.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-O39 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_adenovirus_type_35p Human adenovirus type 35p] with CA as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2O39 OCA].
+O39 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_adenovirus_type_35p Human adenovirus type 35p] with <scene name='pdbligand=CA:'>CA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2O39 OCA].
 ==Reference==
@@ Line 19: / Line 18: @@
 [[Category: Protein complex]]
 [[Category: Arnberg, N.]]
-[[Category: Persson, D.B.]]
+[[Category: Persson, D B.]]
-[[Category: Reiter, D.M.]]
+[[Category: Reiter, D M.]]
 [[Category: Stehle, T.]]
 [[Category: CA]]
@@ Line 35: / Line 34: @@
 [[Category: virus receptor complex]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:06:04 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:13:59 2008''