2gcs: Difference between revisions

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[[Image:2gcs.~~gif~~|left|200px]]

[[Image:2gcs.png|left|200px]]

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~~'''~~Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme~~'''~~

===Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme===

~~==Overview==~~

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The ~~glmS ribozyme is the only natural catalytic RNA known to require a small-molecule activator for catalysis. This catalytic RNA functions as a riboswitch~~, ~~with activator-dependent RNA cleavage regulating glmS messenger RNA expression. We report crystal structures of~~ the ~~glmS ribozyme in precleavage states that are unliganded or bound~~ to the ~~competitive inhibitor glucose-6-phosphate and in the postcleavage state~~. ~~All structures superimpose closely, revealing a remarkably rigid RNA that contains a preformed active and coenzyme-binding site~~. ~~Unlike other riboswitches~~, the ~~glmS ribozyme binds its activator in an open, solvent-accessible pocket~~. ~~Our structures suggest that the amine group of the glmS ribozyme~~-~~bound coenzyme performs general acid~~-~~base and electrostatic catalysis.~~

The line below this paragraph, {{ABSTRACT_PUBMED_16990543}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16990543 is the PubMed ID number.

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==About this Structure==

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[[Category: Ribozyme]]

[[Category: Rna]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 04~~:57:36 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:38:38 2008''

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-[[Image:2gcs.gif|left|200px]]
+{{Seed}}
+[[Image:2gcs.png|left|200px]]
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 {{STRUCTURE_2gcs|  PDB=2gcs  |  SCENE=  }}
-'''Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme'''
+===Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme===
-==Overview==
+<!--
-The glmS ribozyme is the only natural catalytic RNA known to require a small-molecule activator for catalysis. This catalytic RNA functions as a riboswitch, with activator-dependent RNA cleavage regulating glmS messenger RNA expression. We report crystal structures of the glmS ribozyme in precleavage states that are unliganded or bound to the competitive inhibitor glucose-6-phosphate and in the postcleavage state. All structures superimpose closely, revealing a remarkably rigid RNA that contains a preformed active and coenzyme-binding site. Unlike other riboswitches, the glmS ribozyme binds its activator in an open, solvent-accessible pocket. Our structures suggest that the amine group of the glmS ribozyme-bound coenzyme performs general acid-base and electrostatic catalysis.
+The line below this paragraph, {{ABSTRACT_PUBMED_16990543}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16990543 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16990543}}
 ==About this Structure==
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 [[Category: Ribozyme]]
 [[Category: Rna]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:57:36 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:38:38 2008''