2gcz: Difference between revisions

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[[Image:2gcz.~~gif~~|left|200px]]

[[Image:2gcz.png|left|200px]]

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~~'''~~Solution Structure of alpha-Conotoxin OmIA~~'''~~

===Solution Structure of alpha-Conotoxin OmIA===

~~==Overview==~~

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~~alpha-Conotoxin OmIA from Conus omaria is~~ the ~~only alpha-conotoxin that shows a approximately 20-fold higher affinity~~ to the ~~alpha3beta2 over the alpha6beta2 subtype of nicotinic acetylcholine receptor~~. ~~We have determined a three-dimensional structure of alpha-conotoxin OmIA by nuclear magnetic resonance spectroscopy~~. ~~alpha-Conotoxin OmIA has an "omega-shaped" overall topology with His(5~~)~~-Asn(12) forming an alpha-helix~~. ~~Structural features of alpha~~-conotoxin OmIA responsible for its selectivity are suggested by comparing its surface characteristics with other functionally related alpha4/7 subfamily conotoxins. Reduced size of the hydrophilic area in alpha-~~conotoxin OmIA seems to be associated with the reduced affinity towards the alpha6beta2 nAChR subtype.~~

The line below this paragraph, {{ABSTRACT_PUBMED_16678128}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16678128 is the PubMed ID number.

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==About this Structure==

Full ~~crystallographic~~ information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GCZ OCA].

Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GCZ OCA].

==Reference==

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[[Category: C-terminal amidation]]

[[Category: Two disulfide bond]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 04~~:57:49 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:18:26 2008''

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-[[Image:2gcz.gif|left|200px]]
+{{Seed}}
+[[Image:2gcz.png|left|200px]]
 <!--
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 {{STRUCTURE_2gcz|  PDB=2gcz  |  SCENE=  }}
-'''Solution Structure of alpha-Conotoxin OmIA'''
+===Solution Structure of alpha-Conotoxin OmIA===
-==Overview==
+<!--
-alpha-Conotoxin OmIA from Conus omaria is the only alpha-conotoxin that shows a approximately 20-fold higher affinity to the alpha3beta2 over the alpha6beta2 subtype of nicotinic acetylcholine receptor. We have determined a three-dimensional structure of alpha-conotoxin OmIA by nuclear magnetic resonance spectroscopy. alpha-Conotoxin OmIA has an "omega-shaped" overall topology with His(5)-Asn(12) forming an alpha-helix. Structural features of alpha-conotoxin OmIA responsible for its selectivity are suggested by comparing its surface characteristics with other functionally related alpha4/7 subfamily conotoxins. Reduced size of the hydrophilic area in alpha-conotoxin OmIA seems to be associated with the reduced affinity towards the alpha6beta2 nAChR subtype.
+The line below this paragraph, {{ABSTRACT_PUBMED_16678128}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16678128 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16678128}}
 ==About this Structure==
-Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GCZ OCA].
+Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GCZ OCA].
 ==Reference==
@@ Line 29: / Line 33: @@
 [[Category: C-terminal amidation]]
 [[Category: Two disulfide bond]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 04:57:49 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:18:26 2008''