1y1a: Difference between revisions
New page: left|200px<br /> <applet load="1y1a" size="450" color="white" frame="true" align="right" spinBox="true" caption="1y1a, resolution 2.30Å" /> '''CRYSTAL STRUCTURE O... |
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==About this Structure== | ==About this Structure== | ||
1Y1A is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA and GSH as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Y1A OCA]]. | 1Y1A is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA and GSH as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Sites: CA1, CA2, CA3 and CA4. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1Y1A OCA]]. | ||
==Reference== | ==Reference== | ||
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[[Category: integrin]] | [[Category: integrin]] | ||
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:17:19 2007'' | ||
Revision as of 10:12, 30 October 2007
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CRYSTAL STRUCTURE OF CALCIUM AND INTEGRIN BINDING PROTEIN
Overview
Calcium- and integrin-binding protein 1 (CIB1) is involved in the process, of platelet aggregation by binding the cytoplasmic tail of the alpha(IIb), subunit of the platelet-specific integrin alpha(Iib)beta(3). Although, poorly understood, it is widely believed that CIB1 acts as a global, signaling regulator because it is expressed in many tissues that do not, express integrin alpha(Iib)beta(3). We report the structure of human CIB1, to a resolution of 2.3 A, crystallized as a dimer. The dimer interface, includes an extensive hydrophobic patch in a crystal form with 80% solvent, content. Although the dimer form of CIB1 may not be physiologically, relevant, this intersub-unit surface is likely to be linked to alpha(IIb), binding and to the binding of other signaling partner proteins. The, ... [(full description)]
About this Structure
1Y1A is a [Single protein] structure of sequence from [Homo sapiens] with CA and GSH as [ligands]. Structure known Active Sites: CA1, CA2, CA3 and CA4. Full crystallographic information is available from [OCA].
Reference
The crystal structure of calcium- and integrin-binding protein 1: insights into redox regulated functions., Blamey CJ, Ceccarelli C, Naik UP, Bahnson BJ, Protein Sci. 2005 May;14(5):1214-21. PMID:15840829
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