2gdo: Difference between revisions

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[[Image:2gdo.jpg|left|200px]]
{{Seed}}
[[Image:2gdo.png|left|200px]]


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{{STRUCTURE_2gdo|  PDB=2gdo  |  SCENE=  }}  
{{STRUCTURE_2gdo|  PDB=2gdo  |  SCENE=  }}  


'''4-(Aminoalkylamino)-3-Benzimidazole-Quinolinones As Potent CHK1 Inhibitors'''
===4-(Aminoalkylamino)-3-Benzimidazole-Quinolinones As Potent CHK1 Inhibitors===




==Overview==
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CHK-1 is one of the key enzymes regulating checkpoints in cellular growth cycles. Novel 4-(amino-alkylamino)-3-benzimidazole-quinolinones were prepared and assayed for their ability to inhibit CHK-1. These compounds are potent cell permeable CHK-1 inhibitors and showed synergistic effect with a DNA-damaging agent, camptothecin.
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{{ABSTRACT_PUBMED_16603354}}


==About this Structure==
==About this Structure==
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[[Category: Serine/threonine-protein kinase]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Transferase]]
[[Category: Transferase]]
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