2ggm: Difference between revisions

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[[Image:2ggm.gif|left|200px]]
{{Seed}}
[[Image:2ggm.png|left|200px]]


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{{STRUCTURE_2ggm|  PDB=2ggm  |  SCENE=  }}  
{{STRUCTURE_2ggm|  PDB=2ggm  |  SCENE=  }}  


'''Human centrin 2 xeroderma pigmentosum group C protein complex'''
===Human centrin 2 xeroderma pigmentosum group C protein complex===




==Overview==
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Human centrin-2 plays a key role in centrosome function and stimulates nucleotide excision repair by binding to the xeroderma pigmentosum group C protein. To determine the structure of human centrin-2 and to develop an understanding of molecular interactions between centrin and xeroderma pigmentosum group C protein, we characterized the crystal structure of calcium-loaded full-length centrin-2 complexed with a xeroderma pigmentosum group C peptide. Our structure shows that the carboxyl-terminal domain of centrin-2 binds this peptide and two calcium atoms, whereas the amino-terminal lobe is in a closed conformation positioned distantly by an ordered alpha-helical linker. A stretch of the amino-terminal domain unique to centrins appears disordered. Two xeroderma pigmentosum group C peptides both bound to centrin-2 also interact to form an alpha-helical coiled-coil. The interface between centrin-2 and each peptide is predominantly nonpolar, and key hydrophobic residues of XPC have been identified that lead us to propose a novel binding motif for centrin.
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{{ABSTRACT_PUBMED_16627479}}


==About this Structure==
==About this Structure==
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[[Category: Dna repair complex]]
[[Category: Dna repair complex]]
[[Category: Ef-hand superfamily]]
[[Category: Ef-hand superfamily]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:05:07 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 05:40:51 2008''

Revision as of 02:40, 29 July 2008

File:2ggm.png

Template:STRUCTURE 2ggm

Human centrin 2 xeroderma pigmentosum group C protein complex

Template:ABSTRACT PUBMED 16627479

About this Structure

2GGM is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of the human centrin 2-xeroderma pigmentosum group C protein complex., Thompson JR, Ryan ZC, Salisbury JL, Kumar R, J Biol Chem. 2006 Jul 7;281(27):18746-52. Epub 2006 Apr 20. PMID:16627479

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