2ghl: Difference between revisions

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[[Image:2ghl.gif|left|200px]]
{{Seed}}
[[Image:2ghl.png|left|200px]]


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{{STRUCTURE_2ghl|  PDB=2ghl  |  SCENE=  }}  
{{STRUCTURE_2ghl|  PDB=2ghl  |  SCENE=  }}  


'''Mutant Mus Musculus P38 Kinase Domain in Complex with Inhibitor PG-874743'''
===Mutant Mus Musculus P38 Kinase Domain in Complex with Inhibitor PG-874743===




==Overview==
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A new class of tumor necrosis factor alpha (TNF-alpha) synthesis inhibitors based on an N-2,4-pyrimidine-N-phenyl-N'-phenyl urea scaffold is described. Many of these compounds showed low-nanomolar activity against lipopolysaccharide stimulated TNF-alpha production. X-ray co-crystallization studies with mutated p38alpha showed that these trisubstituted ureas interact with the ATP-binding pocket in a pseudo-bicyclic conformation brought about by the presence of an intramolecular hydrogen bonding interaction.
The line below this paragraph, {{ABSTRACT_PUBMED_16632356}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 16632356 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16632356}}


==About this Structure==
==About this Structure==
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[[Category: Map kinase p38]]
[[Category: Map kinase p38]]
[[Category: P38]]
[[Category: P38]]
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