2gjy: Difference between revisions

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[[Image:2gjy.jpg|left|200px]]
{{Seed}}
[[Image:2gjy.png|left|200px]]


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{{STRUCTURE_2gjy|  PDB=2gjy  |  SCENE=  }}  
{{STRUCTURE_2gjy|  PDB=2gjy  |  SCENE=  }}  


'''NMR Solution Structure of Tensin1 PTB Domain'''
===NMR Solution Structure of Tensin1 PTB Domain===




==Overview==
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Tensin is a protein confined at those discrete and specialized regions of the plasma membrane, known as focal adhesions. It contains, at the C-terminus, a phosphotyrosine binding (PTB) domain that can interact with the cytoplasmic tail of beta-integrins and is necessary for localization of the protein to cell-matrix adhesions. Here, we present the NMR solution structure of the PTB domain of tensin1. Moreover, through NMR binding studies, we demonstrate that the PTB domain of tensin1 is able to interact with phosphatidylinositol 4, 5-diphosphate (PtIns(4,5)P2) and phosphatidylinositol 4-phosphate (PtIns(4)P), presenting higher affinity for the diphosphorylated inositide. Chemical shift mapping studies reveal a putative PtIns(4,5)P2 binding region that is distinct from the predicted integrin beta-tail recognition site. Heteronuclear NOE experiments, recorded in absence and presence of PtIns(4,5)P2, indicate that the interaction with lipids decreases the flexibility of loop regions, predicted to be important for integrin binding, and thus, proposes a possible correlation between the two distinct binding events. Therefore, our studies suggest that capture of lipids by the PTB domain of tensin1 may play a role for the protein function at focal adhesions.
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{{ABSTRACT_PUBMED_17922498}}


==About this Structure==
==About this Structure==
2GJY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJY OCA].  
2GJY is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GJY OCA].  


==Reference==
==Reference==
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[[Category: Cell adhesion]]
[[Category: Cell adhesion]]
[[Category: Focal adhesion beta sandwich]]
[[Category: Focal adhesion beta sandwich]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:11:37 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:25:19 2008''

Revision as of 00:25, 29 July 2008

File:2gjy.png

Template:STRUCTURE 2gjy

NMR Solution Structure of Tensin1 PTB Domain

Template:ABSTRACT PUBMED 17922498

About this Structure

2GJY is a Single protein structure of sequence from Gallus gallus. Full experimental information is available from OCA.

Reference

The PTB domain of tensin: NMR solution structure and phosphoinositides binding studies., Leone M, Yu EC, Liddington RC, Pasquale EB, Pellecchia M, Biopolymers. 2008 Jan;89(1):86-92. PMID:17922498

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