2gl7: Difference between revisions

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[[Image:2gl7.~~jpg~~|left|200px]]

[[Image:2gl7.png|left|200px]]

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~~'''~~Crystal Structure of a beta-catenin/BCL9/Tcf4 complex~~'''~~

===Crystal Structure of a beta-catenin/BCL9/Tcf4 complex===

~~==Overview==~~

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The ~~canonical Wnt pathway plays critical roles in embryonic development~~, ~~stem cell growth~~, ~~and tumorigenesis. Stimulation of~~ the ~~Wnt pathway leads~~ to the ~~association of beta-catenin with Tcf and BCL9 in the nucleus, resulting in the transactivation of Wnt target genes. We have determined the crystal structure of a beta-catenin~~/~~BCL9~~/~~Tcf-4 triple complex at 2~~.~~6 A resolution~~. ~~Our studies reveal that the beta-catenin binding site of BCL9~~ is distinct from that of most other beta-catenin partners and forms a good target for developing drugs that block canonical Wnt/beta-catenin signaling. The BCL9 beta-catenin binding domain (CBD) forms an alpha helix that binds to the ~~first armadillo repeat of beta-catenin, which can be mutated to prevent beta-catenin binding to BCL9 without affecting cadherin or alpha-catenin binding~~. ~~We also demonstrate that beta~~-~~catenin Y142 phosphorylation, which has been proposed to regulate BCL9~~-~~2 binding, does not directly affect the interaction of beta-catenin with either BCL9 or BCL9-2.~~

The line below this paragraph, {{ABSTRACT_PUBMED_17052462}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 17052462 is the PubMed ID number.

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==About this Structure==

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[[Category: Armadillo repeat]]

[[Category: Protein complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 05~~:13:44 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:20:10 2008''

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-[[Image:2gl7.jpg|left|200px]]
+{{Seed}}
+[[Image:2gl7.png|left|200px]]
 <!--
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 {{STRUCTURE_2gl7|  PDB=2gl7  |  SCENE=  }}
-'''Crystal Structure of a beta-catenin/BCL9/Tcf4 complex'''
+===Crystal Structure of a beta-catenin/BCL9/Tcf4 complex===
-==Overview==
+<!--
-The canonical Wnt pathway plays critical roles in embryonic development, stem cell growth, and tumorigenesis. Stimulation of the Wnt pathway leads to the association of beta-catenin with Tcf and BCL9 in the nucleus, resulting in the transactivation of Wnt target genes. We have determined the crystal structure of a beta-catenin/BCL9/Tcf-4 triple complex at 2.6 A resolution. Our studies reveal that the beta-catenin binding site of BCL9 is distinct from that of most other beta-catenin partners and forms a good target for developing drugs that block canonical Wnt/beta-catenin signaling. The BCL9 beta-catenin binding domain (CBD) forms an alpha helix that binds to the first armadillo repeat of beta-catenin, which can be mutated to prevent beta-catenin binding to BCL9 without affecting cadherin or alpha-catenin binding. We also demonstrate that beta-catenin Y142 phosphorylation, which has been proposed to regulate BCL9-2 binding, does not directly affect the interaction of beta-catenin with either BCL9 or BCL9-2.
+The line below this paragraph, {{ABSTRACT_PUBMED_17052462}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 17052462 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_17052462}}
 ==About this Structure==
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 [[Category: Armadillo repeat]]
 [[Category: Protein complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:13:44 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:20:10 2008''