2gli: Difference between revisions

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[[Image:2gli.jpg|left|200px]]
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[[Image:2gli.png|left|200px]]


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{{STRUCTURE_2gli|  PDB=2gli  |  SCENE=  }}  
{{STRUCTURE_2gli|  PDB=2gli  |  SCENE=  }}  


'''FIVE-FINGER GLI/DNA COMPLEX'''
===FIVE-FINGER GLI/DNA COMPLEX===




==Overview==
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Zinc finger proteins, of the type first discovered in transcription factor IIIA (TFIIIA), are one of the largest and most important families of DNA-binding proteins. The crystal structure of a complex containing the five Zn fingers from the human GLI oncogene and a high-affinity DNA binding site has been determined at 2.6 A resolution. Finger one does not contact the DNA. Fingers two through five bind in the major groove and wrap around the DNA, but lack the simple, strictly periodic arrangement observed in the Zif268 complex. Fingers four and five of GLI make extensive base contacts in a conserved nine base-pair region, and this section of the DNA has a conformation intermediate between B-DNA and A-DNA. Analyzing the GLI complex and comparing it with Zif268 offers new perspectives on Zn finger-DNA recognition.
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{{ABSTRACT_PUBMED_8378770}}


==About this Structure==
==About this Structure==
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[[Category: Pavletich, N P.]]
[[Category: Pavletich, N P.]]
[[Category: Protein/dna complex]]
[[Category: Protein/dna complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:14:30 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:08:04 2008''

Revision as of 12:08, 28 July 2008

File:2gli.png

Template:STRUCTURE 2gli

FIVE-FINGER GLI/DNA COMPLEX

Template:ABSTRACT PUBMED 8378770

About this Structure

2GLI is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a five-finger GLI-DNA complex: new perspectives on zinc fingers., Pavletich NP, Pabo CO, Science. 1993 Sep 24;261(5129):1701-7. PMID:8378770

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