2gnm: Difference between revisions

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[[Image:2gnm.gif|left|200px]]
{{Seed}}
[[Image:2gnm.png|left|200px]]


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{{STRUCTURE_2gnm|  PDB=2gnm  |  SCENE=  }}  
{{STRUCTURE_2gnm|  PDB=2gnm  |  SCENE=  }}  


'''P. angolensis lectin (PAL) treated with EDTA for 39 hours'''
===P. angolensis lectin (PAL) treated with EDTA for 39 hours===




==Overview==
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The interplay between metal binding, carbohydrate binding activity, stability and structure of the lectin from Pterocarpus angolensis was investigated. Removal of the metals leads to a more flexible form of the protein with significantly less conformational stability. Crystal structures of this metal-free form show significant structural rearrangements, although some structural features that allow the binding of sugars are retained. We propose that substitution of an asparagine residue at the start of the C-terminal beta-strand of the legume lectin monomer hinders the trans-isomerization of the cis-peptide bond upon demetallization and constitutes an intramolecular switch governing the isomer state of the non-proline bond and ultimately the lectin phenotype.
The line below this paragraph, {{ABSTRACT_PUBMED_16824540}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16824540}}


==About this Structure==
==About this Structure==
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[[Category: Pal]]
[[Category: Pal]]
[[Category: Sugar complex]]
[[Category: Sugar complex]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:18:44 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:19:12 2008''
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