2gom: Difference between revisions

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[[Image:2gom.jpg|left|200px]]
{{Seed}}
[[Image:2gom.png|left|200px]]


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{{STRUCTURE_2gom|  PDB=2gom  |  SCENE=  }}  
{{STRUCTURE_2gom|  PDB=2gom  |  SCENE=  }}  


'''Crystal structure of Efb-C from Staphylococcus aureus'''
===Crystal structure of Efb-C from Staphylococcus aureus===




==Overview==
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To provide insight into bacterial suppression of complement-mediated immunity, we present here structures of a bacterial complement inhibitory protein, both free and bound to its complement target. The 1.25-A structure of the complement component C3-inhibitory domain of Staphylococcus aureus extracellular fibrinogen-binding protein (Efb-C) demonstrated a helical motif involved in complement regulation, whereas the 2.2-A structure of Efb-C bound to the C3d domain of human C3 allowed insight into the recognition of complement proteins by invading pathogens. Our structure-function studies provided evidence for a previously unrecognized mode of complement inhibition whereby Efb-C binds to native C3 and alters the solution conformation of C3 in a way that renders it unable to participate in successful 'downstream' activation of the complement response.
The line below this paragraph, {{ABSTRACT_PUBMED_17351618}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_17351618}}


==About this Structure==
==About this Structure==
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[[Category: Hammel, M.]]
[[Category: Hammel, M.]]
[[Category: Three-helix closed bundle with left-hand twist]]
[[Category: Three-helix closed bundle with left-hand twist]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:20:33 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:32:26 2008''
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