2gqe: Difference between revisions

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[[Image:2gqe.jpg|left|200px]]
{{Seed}}
[[Image:2gqe.png|left|200px]]


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{{STRUCTURE_2gqe|  PDB=2gqe  |  SCENE=  }}  
{{STRUCTURE_2gqe|  PDB=2gqe  |  SCENE=  }}  


'''Molecular characterization of the Ran binding zinc finger domain'''
===Molecular characterization of the Ran binding zinc finger domain===




==Overview==
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The nuclear pore complex is the gateway for selective traffic between the nucleus and cytoplasm. To learn how building blocks of the pore can create specific docking sites for transport receptors and regulatory factors, we have studied a zinc finger module present in multiple copies within the nuclear pores of higher eukaryotes. All four zinc fingers of human Nup153 were found to bind the small GTPase Ran with dissociation constants ranging between 5 and 40 mum. In addition a fragment of Nup153 encompassing the four tandem zinc fingers was found to bind Ran with similar affinity. NMR structural studies revealed that a representative Nup153 zinc finger adopts the same zinc ribbon structure as the previously characterized Npl4 NZF module. Ran binding was mediated by a three-amino acid motif (Leu(13)/Val(14)/Asn(25)) located within the two zinc coordination loops. Nup153 ZnFs bound GDP and GTP forms of Ran with similar affinities, indicating that this interaction is not influenced by a nucleotide-dependent conformational switch. Taken together, these studies elucidate the Ran-binding interface on Nup153 and, more broadly, provide insight into the versatility of this zinc finger binding module.
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{{ABSTRACT_PUBMED_17426026}}


==About this Structure==
==About this Structure==
2GQE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQE OCA].  
2GQE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GQE OCA].  


==Reference==
==Reference==
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[[Category: Zinc finger]]
[[Category: Zinc finger]]
[[Category: Zinc knuckle]]
[[Category: Zinc knuckle]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:24:02 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:24:57 2008''

Revision as of 11:25, 28 July 2008

File:2gqe.png

Template:STRUCTURE 2gqe

Molecular characterization of the Ran binding zinc finger domain

Template:ABSTRACT PUBMED 17426026

About this Structure

2GQE is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Molecular characterization of the Ran-binding zinc finger domain of Nup153., Higa MM, Alam SL, Sundquist WI, Ullman KS, J Biol Chem. 2007 Jun 8;282(23):17090-100. Epub 2007 Apr 10. PMID:17426026

Page seeded by OCA on Mon Jul 28 14:24:57 2008

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