2gsq: Difference between revisions

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[[Image:2gsq.jpg|left|200px]]
{{Seed}}
[[Image:2gsq.png|left|200px]]


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{{STRUCTURE_2gsq|  PDB=2gsq  |  SCENE=  }}  
{{STRUCTURE_2gsq|  PDB=2gsq  |  SCENE=  }}  


'''GLUTATHIONE S-TRANSFERASE FROM SQUID DIGESTIVE GLAND COMPLEXED WITH S-(3-IODOBENZYL)GLUTATHIONE'''
===GLUTATHIONE S-TRANSFERASE FROM SQUID DIGESTIVE GLAND COMPLEXED WITH S-(3-IODOBENZYL)GLUTATHIONE===




==Overview==
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The crystal structure of the sigma class glutathione transferase from squid digestive gland in complex with S-(3-iodobenzyl)glutathione reveals a third binding site for the glutathione conjugate besides the two in the active sites of the dimer. The additional binding site is near the crystallographic two-fold axis between the two alpha 4-turn-alpha 5 motifs. The principal binding interactions with the conjugate include specific electrostatic interactions between the peptide and the two subunits and a hydrophobic cavity found across the two-fold axis that accommodates the 3-iodobenzyl group. Thus, two identical, symmetry-related but mutually exclusive binding modes for the third conjugate are observed. The hydrophobic pocket is about 14 A from the hydroxyl group of Tyr-7 in the active site. This site is a potential transport binding site for hydrophobic molecules or their glutathione conjugates.
The line below this paragraph, {{ABSTRACT_PUBMED_8710848}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_8710848}}


==About this Structure==
==About this Structure==
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[[Category: Sigma class]]
[[Category: Sigma class]]
[[Category: Squid digestive gland]]
[[Category: Squid digestive gland]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:29:08 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:57:24 2008''

Revision as of 09:57, 27 July 2008

File:2gsq.png

Template:STRUCTURE 2gsq

GLUTATHIONE S-TRANSFERASE FROM SQUID DIGESTIVE GLAND COMPLEXED WITH S-(3-IODOBENZYL)GLUTATHIONE

Template:ABSTRACT PUBMED 8710848

About this Structure

2GSQ is a Single protein structure of sequence from Ommastrephes sloani. Full crystallographic information is available from OCA.

Reference

Location of a potential transport binding site in a sigma class glutathione transferase by x-ray crystallography., Ji X, von Rosenvinge EC, Johnson WW, Armstrong RN, Gilliland GL, Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8208-13. PMID:8710848

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