2ojq: Difference between revisions

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[[Image:2ojq.gif|left|200px]]<br />

[[Image:2ojq.gif|left|200px]]<br /><applet load="2ojq" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="2ojq" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="2ojq, resolution 2.87Å" />

'''Crystal structure of Alix V domain'''<br />

==Overview==

The modular protein Alix is a central node in endosomal-lysosomal, trafficking and the budding of human immunodeficiency virus (HIV)-1. The, Gag p6 protein of HIV-1 contains a LYPx(n)LxxL motif that is required for, Alix-mediated budding and binds a region of Alix spanning residues, 360-702. The structure of this fragment of Alix has the shape of the, letter 'V' and is termed the V domain. The V domain has a topologically, complex arrangement of 11 alpha-helices, with connecting loops that cross, three times between the two arms of the V. The conserved residue Phe676 is, at the center of a large hydrophobic pocket and is crucial for binding to, a peptide model of HIV-1 p6. Overexpression of the V domain inhibits HIV-1, release from cells. This inhibition of release is reversed by mutations, that block binding of the Alix V domain to p6.

The modular protein Alix is a central node in endosomal-lysosomal trafficking and the budding of human immunodeficiency virus (HIV)-1. The Gag p6 protein of HIV-1 contains a LYPx(n)LxxL motif that is required for Alix-mediated budding and binds a region of Alix spanning residues 360-702. The structure of this fragment of Alix has the shape of the letter 'V' and is termed the V domain. The V domain has a topologically complex arrangement of 11 alpha-helices, with connecting loops that cross three times between the two arms of the V. The conserved residue Phe676 is at the center of a large hydrophobic pocket and is crucial for binding to a peptide model of HIV-1 p6. Overexpression of the V domain inhibits HIV-1 release from cells. This inhibition of release is reversed by mutations that block binding of the Alix V domain to p6.

==About this Structure==

2OJQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2OJQ OCA].

2OJQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJQ OCA].

==Reference==

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[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Hurley, J.H.]]

[[Category: Hurley, J H.]]

[[Category: Lee, S.]]

[[Category: helical]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 23~~:12:~~12 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:19:14 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2ojq.gif|left|200px]]<br />
+[[Image:2ojq.gif|left|200px]]<br /><applet load="2ojq" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="2ojq" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="2ojq, resolution 2.87&Aring;" />
 '''Crystal structure of Alix V domain'''<br />
 ==Overview==
-The modular protein Alix is a central node in endosomal-lysosomal, trafficking and the budding of human immunodeficiency virus (HIV)-1. The, Gag p6 protein of HIV-1 contains a LYPx(n)LxxL motif that is required for, Alix-mediated budding and binds a region of Alix spanning residues, 360-702. The structure of this fragment of Alix has the shape of the, letter 'V' and is termed the V domain. The V domain has a topologically, complex arrangement of 11 alpha-helices, with connecting loops that cross, three times between the two arms of the V. The conserved residue Phe676 is, at the center of a large hydrophobic pocket and is crucial for binding to, a peptide model of HIV-1 p6. Overexpression of the V domain inhibits HIV-1, release from cells. This inhibition of release is reversed by mutations, that block binding of the Alix V domain to p6.
+The modular protein Alix is a central node in endosomal-lysosomal trafficking and the budding of human immunodeficiency virus (HIV)-1. The Gag p6 protein of HIV-1 contains a LYPx(n)LxxL motif that is required for Alix-mediated budding and binds a region of Alix spanning residues 360-702. The structure of this fragment of Alix has the shape of the letter 'V' and is termed the V domain. The V domain has a topologically complex arrangement of 11 alpha-helices, with connecting loops that cross three times between the two arms of the V. The conserved residue Phe676 is at the center of a large hydrophobic pocket and is crucial for binding to a peptide model of HIV-1 p6. Overexpression of the V domain inhibits HIV-1 release from cells. This inhibition of release is reversed by mutations that block binding of the Alix V domain to p6.
 ==About this Structure==
-OJQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2OJQ OCA].
+OJQ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OJQ OCA].
 ==Reference==
@@ Line 14: / Line 13: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Hurley, J.H.]]
+[[Category: Hurley, J H.]]
 [[Category: Lee, S.]]
 [[Category: helical]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:12:12 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:19:14 2008''