2gum: Difference between revisions

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[[Image:2gum.gif|left|200px]]
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{{STRUCTURE_2gum|  PDB=2gum  |  SCENE=  }}  
{{STRUCTURE_2gum|  PDB=2gum  |  SCENE=  }}  


'''Crystal structure of the extracellular domain of glycoprotein B from Herpes Simplex Virus type I'''
===Crystal structure of the extracellular domain of glycoprotein B from Herpes Simplex Virus type I===




==Overview==
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Glycoprotein B (gB) is the most conserved component of the complex cell-entry machinery of herpes viruses. A crystal structure of the gB ectodomain from herpes simplex virus type 1 reveals a multidomain trimer with unexpected homology to glycoprotein G from vesicular stomatitis virus (VSV G). An alpha-helical coiled-coil core relates gB to class I viral membrane fusion glycoproteins; two extended beta hairpins with hydrophobic tips, homologous to fusion peptides in VSV G, relate gB to class II fusion proteins. Members of both classes accomplish fusion through a large-scale conformational change, triggered by a signal from a receptor-binding component. The domain connectivity within a gB monomer would permit such a rearrangement, including long-range translocations linked to viral and cellular membranes.
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{{ABSTRACT_PUBMED_16840698}}


==About this Structure==
==About this Structure==
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[[Category: Membrane fusion]]
[[Category: Membrane fusion]]
[[Category: Virus]]
[[Category: Virus]]
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Revision as of 18:34, 28 July 2008

File:2gum.png

Template:STRUCTURE 2gum

Crystal structure of the extracellular domain of glycoprotein B from Herpes Simplex Virus type I

Template:ABSTRACT PUBMED 16840698

About this Structure

2GUM is a Single protein structure of sequence from Human herpesvirus 1. Full crystallographic information is available from OCA.

Reference

Crystal structure of glycoprotein B from herpes simplex virus 1., Heldwein EE, Lou H, Bender FC, Cohen GH, Eisenberg RJ, Harrison SC, Science. 2006 Jul 14;313(5784):217-20. PMID:16840698

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