2opy: Difference between revisions

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[[Image:2opy.gif|left|200px]]<br />

[[Image:2opy.gif|left|200px]]<br /><applet load="2opy" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="2opy" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="2opy, resolution 2.8Å" />

'''Smac mimic bound to BIR3-XIAP'''<br />

==Overview==

A small series of peptide mimics was designed and synthesized to contain a, heterocyclic ring in place of the potentially labile N-terminal peptide, bond of the tetrapeptide containing the Smac-XIAP-binding motif. Two Smac, mimics were shown to bind to the BIR3 domain of XIAP with moderate, affinity and one displayed increased activity in cells relative to the, Smac peptides. The structures of BIR3-XIAP in complex with a Smac peptide, and a peptide mimic were solved and analyzed to elucidate the, structure-activity relationship surrounding the Smac-binding domain within, BIR3-XIAP.

A small series of peptide mimics was designed and synthesized to contain a heterocyclic ring in place of the potentially labile N-terminal peptide bond of the tetrapeptide containing the Smac-XIAP-binding motif. Two Smac mimics were shown to bind to the BIR3 domain of XIAP with moderate affinity and one displayed increased activity in cells relative to the Smac peptides. The structures of BIR3-XIAP in complex with a Smac peptide and a peptide mimic were solved and analyzed to elucidate the structure-activity relationship surrounding the Smac-binding domain within BIR3-XIAP.

==Disease==

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==About this Structure==

2OPY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN and CO9 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=2OPY OCA].

2OPY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=CO9:'>CO9</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPY OCA].

==Reference==

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[[Category: Single protein]]

[[Category: Lu, G.]]

[[Category: McLendon, G.L.]]

[[Category: McLendon, G L.]]

[[Category: Riedl, S.J.]]

[[Category: Riedl, S J.]]

[[Category: Shi, Y.]]

[[Category: Wist, A.D.]]

[[Category: Wist, A D.]]

[[Category: CO9]]

[[Category: ZN]]

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[[Category: peptide mimic]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 23~~:14~~:44 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:21:14 2008''

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@@ Line 1: / Line 1: @@
-[[Image:2opy.gif|left|200px]]<br />
+[[Image:2opy.gif|left|200px]]<br /><applet load="2opy" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="2opy" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="2opy, resolution 2.8&Aring;" />
 '''Smac mimic bound to BIR3-XIAP'''<br />
 ==Overview==
-A small series of peptide mimics was designed and synthesized to contain a, heterocyclic ring in place of the potentially labile N-terminal peptide, bond of the tetrapeptide containing the Smac-XIAP-binding motif. Two Smac, mimics were shown to bind to the BIR3 domain of XIAP with moderate, affinity and one displayed increased activity in cells relative to the, Smac peptides. The structures of BIR3-XIAP in complex with a Smac peptide, and a peptide mimic were solved and analyzed to elucidate the, structure-activity relationship surrounding the Smac-binding domain within, BIR3-XIAP.
+A small series of peptide mimics was designed and synthesized to contain a heterocyclic ring in place of the potentially labile N-terminal peptide bond of the tetrapeptide containing the Smac-XIAP-binding motif. Two Smac mimics were shown to bind to the BIR3 domain of XIAP with moderate affinity and one displayed increased activity in cells relative to the Smac peptides. The structures of BIR3-XIAP in complex with a Smac peptide and a peptide mimic were solved and analyzed to elucidate the structure-activity relationship surrounding the Smac-binding domain within BIR3-XIAP.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-OPY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN and CO9 as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2OPY OCA].
+OPY is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene> and <scene name='pdbligand=CO9:'>CO9</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OPY OCA].
 ==Reference==
@@ Line 18: / Line 17: @@
 [[Category: Single protein]]
 [[Category: Lu, G.]]
-[[Category: McLendon, G.L.]]
+[[Category: McLendon, G L.]]
-[[Category: Riedl, S.J.]]
+[[Category: Riedl, S J.]]
 [[Category: Shi, Y.]]
-[[Category: Wist, A.D.]]
+[[Category: Wist, A D.]]
 [[Category: CO9]]
 [[Category: ZN]]
@@ Line 27: / Line 26: @@
 [[Category: peptide mimic]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 23:14:44 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 18:21:14 2008''