2h0n: Difference between revisions

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{{Seed}}
[[Image:2h0n.png|left|200px]]
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{{STRUCTURE_2h0n|  PDB=2h0n  |  SCENE=  }}  
{{STRUCTURE_2h0n|  PDB=2h0n  |  SCENE=  }}  


'''Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC'''
===Structure of the fully modified left-handed cyclohexene nucleic acid sequence GTGTACAC===




==Overview==
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CeNA oligonucleotides consist of a phosphorylated backbone where the deoxyribose sugars are replaced by cyclohexene moieties. The X-ray structure determination and analysis of a fully modified octamer sequence GTGTACAC, which is the first crystal structure of a carbocyclic-based nucleic acid, is presented. This particular sequence was built with left-handed building blocks and crystallizes as a left-handed double helix. The helix can be characterized as belonging to the (mirrored) A-type family. Crystallographic data were processed up to 1.53 A, and the octamer sequence crystallizes in the space group R32. The sugar puckering is found to adopt the 3H2 half-chair conformation which mimics the C3'-endo conformation of the ribose sugar. The double helices stack on top of each other to form continuous helices, and static disorder is observed due to this end-to-end stacking.
The line below this paragraph, {{ABSTRACT_PUBMED_18198873}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_18198873}}


==About this Structure==
==About this Structure==
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[[Category: Double helix]]
[[Category: Double helix]]
[[Category: Left-handed]]
[[Category: Left-handed]]
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