2h0x: Difference between revisions

Line 1:

[[Image:2h0x.~~gif~~|left|200px]]

[[Image:2h0x.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme~~'''~~

===Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme===

~~==Overview==~~

<!--

The ~~glmS ribozyme is the only natural catalytic RNA known to require a small-molecule activator for catalysis. This catalytic RNA functions as a riboswitch~~, ~~with activator-dependent RNA cleavage regulating glmS messenger RNA expression. We report crystal structures of~~ the ~~glmS ribozyme in precleavage states that are unliganded or bound~~ to the ~~competitive inhibitor glucose-6-phosphate and in the postcleavage state~~. ~~All structures superimpose closely, revealing a remarkably rigid RNA that contains a preformed active and coenzyme-binding site~~. ~~Unlike other riboswitches~~, the ~~glmS ribozyme binds its activator in an open, solvent-accessible pocket~~. ~~Our structures suggest that the amine group of the glmS ribozyme~~-~~bound coenzyme performs general acid~~-~~base and electrostatic catalysis.~~

The line below this paragraph, {{ABSTRACT_PUBMED_16990543}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16990543 is the PubMed ID number.

-->

==About this Structure==

Line 27:

Line 31:

[[Category: Ribozyme]]

[[Category: Rna]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 05~~:44:18 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:20:53 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:2h0x.gif|left|200px]]
+{{Seed}}
+[[Image:2h0x.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2h0x|  PDB=2h0x  |  SCENE=  }}
-'''Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme'''
+===Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme===
-==Overview==
+<!--
-The glmS ribozyme is the only natural catalytic RNA known to require a small-molecule activator for catalysis. This catalytic RNA functions as a riboswitch, with activator-dependent RNA cleavage regulating glmS messenger RNA expression. We report crystal structures of the glmS ribozyme in precleavage states that are unliganded or bound to the competitive inhibitor glucose-6-phosphate and in the postcleavage state. All structures superimpose closely, revealing a remarkably rigid RNA that contains a preformed active and coenzyme-binding site. Unlike other riboswitches, the glmS ribozyme binds its activator in an open, solvent-accessible pocket. Our structures suggest that the amine group of the glmS ribozyme-bound coenzyme performs general acid-base and electrostatic catalysis.
+The line below this paragraph, {{ABSTRACT_PUBMED_16990543}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16990543 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16990543}}
 ==About this Structure==
@@ Line 27: / Line 31: @@
 [[Category: Ribozyme]]
 [[Category: Rna]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:44:18 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:20:53 2008''