2h0z: Difference between revisions

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[[Image:2h0z.gif|left|200px]]
{{Seed}}
[[Image:2h0z.png|left|200px]]


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{{STRUCTURE_2h0z|  PDB=2h0z  |  SCENE=  }}  
{{STRUCTURE_2h0z|  PDB=2h0z  |  SCENE=  }}  


'''Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme bound to glucose-6-phosphate'''
===Pre-cleavage state of the Thermoanaerobacter tengcongensis glmS ribozyme bound to glucose-6-phosphate===




==Overview==
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The glmS ribozyme is the only natural catalytic RNA known to require a small-molecule activator for catalysis. This catalytic RNA functions as a riboswitch, with activator-dependent RNA cleavage regulating glmS messenger RNA expression. We report crystal structures of the glmS ribozyme in precleavage states that are unliganded or bound to the competitive inhibitor glucose-6-phosphate and in the postcleavage state. All structures superimpose closely, revealing a remarkably rigid RNA that contains a preformed active and coenzyme-binding site. Unlike other riboswitches, the glmS ribozyme binds its activator in an open, solvent-accessible pocket. Our structures suggest that the amine group of the glmS ribozyme-bound coenzyme performs general acid-base and electrostatic catalysis.
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{{ABSTRACT_PUBMED_16990543}}


==About this Structure==
==About this Structure==
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[[Category: Ribozyme]]
[[Category: Ribozyme]]
[[Category: Rna]]
[[Category: Rna]]
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