2h32: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,097 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,097 edits
No edit summary
Line 1: Line 1:
[[Image:2h32.jpg|left|200px]]
{{Seed}}
[[Image:2h32.png|left|200px]]


<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2h32|  PDB=2h32  |  SCENE=  }}  
{{STRUCTURE_2h32|  PDB=2h32  |  SCENE=  }}  


'''Crystal structure of the pre-B cell receptor'''
===Crystal structure of the pre-B cell receptor===




==Overview==
<!--
The pre-B cell receptor (pre-BCR) serves as a checkpoint in B cell development. In the 2.7 angstrom structure of a human pre-BCR Fab-like fragment, consisting of an antibody heavy chain (HC) paired with the surrogate light chain, the "unique regions" of VpreB and lambda5 replace the complementarity-determining region 3 (CDR3) loop of an antibody light chain and appear to "probe" the HC CDR3, potentially influencing the selection of the antibody repertoire. Biochemical analysis indicates that the pre-BCR is impaired in its ability to recognize antigen, which, together with electron microscopic visualization of a pre-BCR dimer, suggests ligand-independent oligomerization as the likely signaling mechanism.
The line below this paragraph, {{ABSTRACT_PUBMED_17431183}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 17431183 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_17431183}}


==About this Structure==
==About this Structure==
Line 25: Line 29:
[[Category: Beta sheet]]
[[Category: Beta sheet]]
[[Category: V and c-type ig fold]]
[[Category: V and c-type ig fold]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:48:37 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 07:03:34 2008''
Retrieved from "https://proteopedia.org/2h32"