2h3b: Difference between revisions

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[[Image:2h3b.gif|left|200px]]
{{Seed}}
[[Image:2h3b.png|left|200px]]


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{{STRUCTURE_2h3b|  PDB=2h3b  |  SCENE=  }}  
{{STRUCTURE_2h3b|  PDB=2h3b  |  SCENE=  }}  


'''Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor 1'''
===Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor 1===




==Overview==
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Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirT1 activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism.
The line below this paragraph, {{ABSTRACT_PUBMED_16783373}}, adds the Publication Abstract to the page
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{{ABSTRACT_PUBMED_16783373}}


==About this Structure==
==About this Structure==
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[[Category: Apoenzyme]]
[[Category: Apoenzyme]]
[[Category: Type ii phsophoribosyltransferase]]
[[Category: Type ii phsophoribosyltransferase]]
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