2h3d: Difference between revisions

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[[Image:2h3d.gif|left|200px]]
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{{STRUCTURE_2h3d|  PDB=2h3d  |  SCENE=  }}  
{{STRUCTURE_2h3d|  PDB=2h3d  |  SCENE=  }}  


'''Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor in Complex with Nicotinamide Mononuleotide'''
===Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor in Complex with Nicotinamide Mononuleotide===




==Overview==
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Nicotinamide phosphoribosyltransferase (Nampt) synthesizes nicotinamide mononucleotide (NMN) from nicotinamide in a mammalian NAD+ biosynthetic pathway and is required for SirT1 activity in vivo. Nampt has also been presumed to be a cytokine (PBEF) or a hormone (visfatin). The crystal structure of Nampt in the presence and absence of NMN shows that Nampt is a dimeric type II phosphoribosyltransferase and provides insights into the enzymatic mechanism.
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{{ABSTRACT_PUBMED_16783373}}


==About this Structure==
==About this Structure==
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[[Category: Nmn]]
[[Category: Nmn]]
[[Category: Typeii phsophoribosyltransferase]]
[[Category: Typeii phsophoribosyltransferase]]
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Revision as of 09:35, 28 July 2008

File:2h3d.png

Template:STRUCTURE 2h3d

Crystal Structure of Mouse Nicotinamide Phosphoribosyltransferase/Visfatin/Pre-B Cell Colony Enhancing Factor in Complex with Nicotinamide Mononuleotide

Template:ABSTRACT PUBMED 16783373

About this Structure

2H3D is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme., Wang T, Zhang X, Bheda P, Revollo JR, Imai S, Wolberger C, Nat Struct Mol Biol. 2006 Jul;13(7):661-2. Epub 2006 Jun 18. PMID:16783373

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