2h4p: Difference between revisions

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[[Image:2h4p.gif|left|200px]]
{{Seed}}
[[Image:2h4p.png|left|200px]]


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{{STRUCTURE_2h4p|  PDB=2h4p  |  SCENE=  }}  
{{STRUCTURE_2h4p|  PDB=2h4p  |  SCENE=  }}  


'''Crystal structure of wildtype MENT in the cleaved conformation'''
===Crystal structure of wildtype MENT in the cleaved conformation===




==Overview==
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Most serpins are associated with protease inhibition, and their ability to form loop-sheet polymers is linked to conformational disease and the human serpinopathies. Here we describe the structural and functional dissection of how a unique serpin, the non-histone architectural protein, MENT (Myeloid and Erythroid Nuclear Termination stage-specific protein), participates in DNA and chromatin condensation. Our data suggest that MENT contains at least two distinct DNA-binding sites, consistent with its simultaneous binding to the two closely juxtaposed linker DNA segments on a nucleosome. Remarkably, our studies suggest that the reactive centre loop, a region of the MENT molecule essential for chromatin bridging in vivo and in vitro, is able to mediate formation of a loop-sheet oligomer. These data provide mechanistic insight into chromatin compaction by a non-histone architectural protein and suggest how the structural plasticity of serpins has adapted to mediate physiological, rather than pathogenic, loop-sheet linkages.
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{{ABSTRACT_PUBMED_16810322}}


==About this Structure==
==About this Structure==
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[[Category: Serine protease inhibitor]]
[[Category: Serine protease inhibitor]]
[[Category: Serpin]]
[[Category: Serpin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:51:44 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 06:38:57 2008''

Revision as of 03:39, 28 July 2008

File:2h4p.png

Template:STRUCTURE 2h4p

Crystal structure of wildtype MENT in the cleaved conformation

Template:ABSTRACT PUBMED 16810322

About this Structure

2H4P is a Protein complex structure of sequences from Gallus gallus. Full crystallographic information is available from OCA.

Reference

X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation., McGowan S, Buckle AM, Irving JA, Ong PC, Bashtannyk-Puhalovich TA, Kan WT, Henderson KN, Bulynko YA, Popova EY, Smith AI, Bottomley SP, Rossjohn J, Grigoryev SA, Pike RN, Whisstock JC, EMBO J. 2006 Jul 12;25(13):3144-55. Epub 2006 Jun 29. PMID:16810322

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