2h68: Difference between revisions

Line 1:

[[Image:2h68.~~gif~~|left|200px]]

[[Image:2h68.png|left|200px]]

<!--

Line 9:

Line 10:

~~'''~~Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex~~'''~~

===Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex===

~~==Overview==~~

<!--

~~WDR5 is a core component of SET1-family complexes that achieve transcriptional activation via methylation of histone H3 on Nzeta of Lys4 (H3K4).~~ The role of WDR5 in the MLL1 complex has recently been described as specific recognition of dimethyl-K4 in the context of a histone H3 amino terminus; WDR5 is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. We report the high-resolution X-ray structures of WDR5 in the unliganded form and complexed with histone H3 peptides having unmodified and mono-, ~~di- and trimethylated K4~~, ~~which together provide~~ the ~~first comprehensive analysis of methylated histone recognition by~~ the ~~ubiquitous WD40-repeat fold~~. ~~Contrary to predictions~~, the ~~structures reveal that WDR5 does not read out the methylation state of K4 directly, but instead serves to present the K4 side chain for further methylation by SET1~~-~~family complexes.~~

The line below this paragraph, {{ABSTRACT_PUBMED_16829959}}, adds the Publication Abstract to the page

(as it appears on PubMed at http://www.pubmed.gov), where 16829959 is the PubMed ID number.

-->

==About this Structure==

Line 30:

Line 34:

[[Category: Wang, W K.]]

[[Category: Wd40 wd-repeat histone modification chromatin]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Sun May 4 05~~:55:00 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:13:06 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:2h68.gif|left|200px]]
+{{Seed}}
+[[Image:2h68.png|left|200px]]
 <!--
@@ Line 9: / Line 10: @@
 {{STRUCTURE_2h68|  PDB=2h68  |  SCENE=  }}
-'''Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex'''
+===Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex===
-==Overview==
+<!--
-WDR5 is a core component of SET1-family complexes that achieve transcriptional activation via methylation of histone H3 on Nzeta of Lys4 (H3K4). The role of WDR5 in the MLL1 complex has recently been described as specific recognition of dimethyl-K4 in the context of a histone H3 amino terminus; WDR5 is essential for vertebrate development, Hox gene activation and global H3K4 trimethylation. We report the high-resolution X-ray structures of WDR5 in the unliganded form and complexed with histone H3 peptides having unmodified and mono-, di- and trimethylated K4, which together provide the first comprehensive analysis of methylated histone recognition by the ubiquitous WD40-repeat fold. Contrary to predictions, the structures reveal that WDR5 does not read out the methylation state of K4 directly, but instead serves to present the K4 side chain for further methylation by SET1-family complexes.
+The line below this paragraph, {{ABSTRACT_PUBMED_16829959}}, adds the Publication Abstract to the page
+(as it appears on PubMed at http://www.pubmed.gov), where 16829959 is the PubMed ID number.
+-->
+{{ABSTRACT_PUBMED_16829959}}
 ==About this Structure==
@@ Line 30: / Line 34: @@
 [[Category: Wang, W K.]]
 [[Category: Wd40 wd-repeat histone modification chromatin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:55:00 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 16:13:06 2008''