2h6t: Difference between revisions

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[[Image:2h6t.jpg|left|200px]]
{{Seed}}
[[Image:2h6t.png|left|200px]]


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{{STRUCTURE_2h6t|  PDB=2h6t  |  SCENE=  }}  
{{STRUCTURE_2h6t|  PDB=2h6t  |  SCENE=  }}  


'''Secreted aspartic proteinase (Sap) 3 from Candida albicans complexed with pepstatin A'''
===Secreted aspartic proteinase (Sap) 3 from Candida albicans complexed with pepstatin A===




==Overview==
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The family of secreted aspartic proteinases (Sap) encoded by 10 SAP genes is an important virulence factor during Candida albicans (C. albicans) infections. Antagonists to Saps could be envisioned to help prevent or treat candidosis in immunocompromised patients. The knowledge of several Sap structures is crucial for inhibitor design; only the structure of Sap2 is known. We report the 1.9 and 2.2 A resolution X-ray crystal structures of Sap3 in a stable complex with pepstatin A and in the absence of an inhibitor, shedding further light on the enzyme inhibitor binding. Inhibitor binding causes active site closure by the movement of a flap segment. Comparison of the structures of Sap3 and Sap2 identifies elements responsible for the specificity of each isoenzyme.
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{{ABSTRACT_PUBMED_17510964}}


==About this Structure==
==About this Structure==
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[[Category: Aspartic proteinase]]
[[Category: Aspartic proteinase]]
[[Category: Hydrolase]]
[[Category: Hydrolase]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May  4 05:56:12 2008''
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 12:49:15 2008''

Revision as of 09:49, 29 July 2008

File:2h6t.png

Template:STRUCTURE 2h6t

Secreted aspartic proteinase (Sap) 3 from Candida albicans complexed with pepstatin A

Template:ABSTRACT PUBMED 17510964

About this Structure

2H6T is a Single protein structure of sequence from Candida albicans. Full crystallographic information is available from OCA.

Reference

The crystal structure of the secreted aspartic proteinase 3 from Candida albicans and its complex with pepstatin A., Borelli C, Ruge E, Schaller M, Monod M, Korting HC, Huber R, Maskos K, Proteins. 2007 Aug 15;68(3):738-48. PMID:17510964

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