2h9s: Difference between revisions

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[[Image:2h9s.gif|left|200px]]
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[[Image:2h9s.png|left|200px]]


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{{STRUCTURE_2h9s|  PDB=2h9s  |  SCENE=  }}  
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'''Crystal Structure of Homo-DNA and Nature's Choice of Pentose over Hexose in the Genetic System'''
===Crystal Structure of Homo-DNA and Nature's Choice of Pentose over Hexose in the Genetic System===




==Overview==
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An experimental rationalization of the structure type encountered in DNA and RNA by systematically investigating the chemical and physical properties of alternative nucleic acids has identified systems with a variety of sugar-phosphate backbones that are capable of Watson-Crick base pairing and in some cases cross-pairing with the natural nucleic acids. The earliest among the model systems tested to date, (4' --&gt; 6')-linked oligo(2',3'-dideoxy-beta-d-glucopyranosyl)nucleotides or homo-DNA, shows stable self-pairing, but the pairing rules for the four natural bases are not the same as those in DNA. However, a complete interpretation and understanding of the properties of the hexapyranosyl (4' --&gt; 6') family of nucleic acids has been impeded until now by the lack of detailed 3D-structural data. We have determined the crystal structure of a homo-DNA octamer. It reveals a weakly twisted right-handed duplex with a strong inclination between the hexose-phosphate backbones and base-pair axes, and highly irregular values for helical rise and twist at individual base steps. The structure allows a rationalization of the inability of allo-, altro-, and glucopyranosyl-based oligonucleotides to form stable pairing systems.
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{{ABSTRACT_PUBMED_16910680}}


==About this Structure==
==About this Structure==
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[[Category: Homo-dna]]
[[Category: Homo-dna]]
[[Category: Homo-dna crystal structure]]
[[Category: Homo-dna crystal structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:43:11 2008''

Revision as of 13:43, 27 July 2008

File:2h9s.png

Template:STRUCTURE 2h9s

Crystal Structure of Homo-DNA and Nature's Choice of Pentose over Hexose in the Genetic System

Template:ABSTRACT PUBMED 16910680

About this Structure

Full crystallographic information is available from OCA.

Reference

Crystal structure of homo-DNA and nature's choice of pentose over hexose in the genetic system., Egli M, Pallan PS, Pattanayek R, Wilds CJ, Lubini P, Minasov G, Dobler M, Leumann CJ, Eschenmoser A, J Am Chem Soc. 2006 Aug 23;128(33):10847-56. PMID:16910680

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